Skibska Beata, Goraca Anna
Department of Applied Pharmacy, Department of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
Department of Cardiovascular Physiology, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Oxid Med Cell Longev. 2015;2015:313021. doi: 10.1155/2015/313021. Epub 2015 Apr 8.
Oxidative stress is considered to be the primary cause of many cardiovascular diseases, including endothelial dysfunction in atherosclerosis and ischemic heart disease, hypertension, and heart failure. Oxidative stress increases during the aging process, resulting in either increased reactive oxygen species (ROS) production or decreased antioxidant defense. The increase in the incidence of cardiovascular disease is directly related to age. Aging is also associated with oxidative stress, which in turn leads to accelerated cellular senescence and organ dysfunction. Antioxidants may help lower the incidence of some pathologies of cardiovascular diseases and have antiaging properties. Lipoic acid (LA) is a natural antioxidant which is believed to have a beneficial effect on oxidative stress parameters in relation to diseases of the cardiovascular system.
氧化应激被认为是许多心血管疾病的主要原因，包括动脉粥样硬化和缺血性心脏病中的内皮功能障碍、高血压和心力衰竭。在衰老过程中氧化应激会增加，导致活性氧（ROS）生成增加或抗氧化防御能力下降。心血管疾病发病率的增加与年龄直接相关。衰老还与氧化应激有关，而氧化应激反过来又会导致细胞衰老加速和器官功能障碍。抗氧化剂可能有助于降低某些心血管疾病的发病率，并具有抗衰老特性。硫辛酸（LA）是一种天然抗氧化剂，据信它对心血管系统疾病的氧化应激参数具有有益作用。
