Department of Epidemiology, Rollins School of Public Health, Emory University, Claudia Nance Rollins Building (CNR), Room 3051, 1518 Clifton Road NE, Atlanta, GA 30322, USA.
Public Health Nutr. 2013 Feb;16(2):289-95. doi: 10.1017/S1368980012001267. Epub 2012 May 21.
To assess the association of the acute-phase protein biomarkers, C-reactive protein (CRP) and α1-acid glycoprotein (AGP), with anaemia in children aged 6-59·9 months in Papua New Guinea.
A nationally representative household-based cross-sectional survey of children aged 6-59·9 months was used to assess the relationships between various combinations of elevated CRP (>5 mg/l) and AGP (>1·2 g/l) with anaemia. Logistic regression was used to determine if other factors, such as age, sex, measures of anthropometry, region, urban/rural residence and household size, modified or confounded the acute-phase protein-anaemia association.
Papua New Guinea.
A total of 870 children aged 6-59·9 months from the 2005 Papua New Guinea National Micronutrient Survey were assessed.
The following prevalence estimates were found: anaemia 48 %; elevated CRP 32 %; and elevated AGP 33 %. Children with elevated CRP had a prevalence of anaemia of 66 % compared with children with normal CRP who had a prevalence of 40 %. Corresponding estimates for AGP were 61 % and 42 %, respectively. Similar results were found with combinations of elevated CRP and AGP. The higher prevalence of anaemia in children with elevated CRP and/or AGP was still present after controlling for confounders.
Elevated levels of CRP and AGP were significantly associated with a higher prevalence of anaemia in the children surveyed. There are no expert group recommendations on whether to or how to account for markers of inflammation in presenting results on anaemia prevalence. Additional research would be helpful to clarify this issue.
评估急性蛋白生物标志物 C 反应蛋白（CRP）和α1-酸性糖蛋白（AGP）与巴布亚新几内亚 6-59.9 月龄儿童贫血的关系。
采用全国代表性的 6-59.9 月龄儿童家庭横断面调查，评估 CRP（>5mg/L）和 AGP（>1.2g/L）升高的不同组合与贫血之间的关系。采用逻辑回归确定年龄、性别、人体测量指标、地区、城乡居住和家庭规模等其他因素是否改变或混淆了急性期蛋白与贫血的关系。
巴布亚新几内亚。
来自 2005 年巴布亚新几内亚国家微量营养素调查的 870 名 6-59.9 月龄儿童。
发现以下患病率估计值：贫血 48%；CRP 升高 32%；AGP 升高 33%。CRP 升高的儿童贫血患病率为 66%，而 CRP 正常的儿童贫血患病率为 40%。AGP 的相应估计值分别为 61%和 42%。CRP 和 AGP 升高的组合也有类似的结果。在控制了混杂因素后，CRP 和/或 AGP 升高的儿童贫血患病率仍然较高。
CRP 和 AGP 水平升高与调查儿童贫血患病率升高显著相关。专家组没有关于是否以及如何在报告贫血患病率结果时考虑炎症标志物的建议。进一步的研究将有助于澄清这一问题。
