嗜碱性粒细胞诱导 Th2 免疫：这是最终答案吗？
Basophils induce Th2 immunity: is this final answer?
机构信息
Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
出版信息
Virulence. 2010 Sep-Oct;1(5):399-401. doi: 10.4161/viru.1.5.12550.
Abstract
Despite that basophils represent less than 0.5% of circulating leukocytes, recent studies have begun to unveil their potent immunoregulatory functions, i.e., induction of Th2 immunity. It is believed that basophils are capable of doing so primarily by secreting key Th2-inducing cytokines, namely IL-4 and Thymic Stromal Lymphopoietin (TSLP), and by functioning as professional antigen presenting cells. However, we have recently demonstrated that Th2 immunity can develop in the absence of basophils or IL-4 during helminth infection. In this review, how basophils may (and may not) contribute to the development of Th2 immunity in vivo is discussed.
摘要
尽管嗜碱性粒细胞在循环白细胞中所占比例不到 0.5%，但最近的研究开始揭示其强大的免疫调节功能，即诱导 Th2 免疫。人们认为嗜碱性粒细胞主要通过分泌关键的 Th2 诱导细胞因子，即白细胞介素 4 和胸腺基质淋巴细胞生成素 (TSLP)，并作为专业的抗原提呈细胞来实现这一点。然而，我们最近证明，在寄生虫感染期间，在没有嗜碱性粒细胞或白细胞介素 4 的情况下也可以发展 Th2 免疫。在这篇综述中，讨论了嗜碱性粒细胞在体内可能（和不可能）促进 Th2 免疫的发展。
相似文献
1
Basophils induce Th2 immunity: is this final answer?嗜碱性粒细胞诱导 Th2 免疫：这是最终答案吗？
Virulence. 2010 Sep-Oct;1(5):399-401. doi: 10.4161/viru.1.5.12550.
2
Thymic stromal lymphopoietin-dependent basophils promote Th2 cytokine responses following intestinal helminth infection.胸腺基质淋巴细胞生成素依赖性嗜碱性粒细胞促进肠道蠕虫感染后的 Th2 细胞因子反应。
J Immunol. 2012 Nov 1;189(9):4371-8. doi: 10.4049/jimmunol.1200691. Epub 2012 Sep 28.
3
[TSLP-basophil axis].[胸腺基质淋巴细胞生成素-嗜碱性粒细胞轴]
Nihon Yakurigaku Zasshi. 2014 Feb;143(2):103-4. doi: 10.1254/fpj.143.103.
4
IL-37 Targets TSLP-Primed Basophils to Alleviate Atopic Dermatitis.IL-37 通过靶向 TSLP 致敏的嗜碱性粒细胞缓解特应性皮炎。
Int J Mol Sci. 2021 Jul 9;22(14):7393. doi: 10.3390/ijms22147393.
5
Functional heterogeneity in the basophil cell lineage.嗜碱性粒细胞系的功能异质性。
Adv Immunol. 2012;115:141-59. doi: 10.1016/B978-0-12-394299-9.00005-9.
6
Innate and adaptive type 2 immunity in lung allergic inflammation.肺部过敏性炎症中的固有性和适应性2型免疫
Immunol Rev. 2017 Jul;278(1):162-172. doi: 10.1111/imr.12557.
7
Basophil-derived IL-4 promotes epicutaneous antigen sensitization concomitant with the development of food allergy.嗜碱性粒细胞衍生的 IL-4 促进经皮抗原致敏，同时伴发食物过敏。
J Allergy Clin Immunol. 2018 Jan;141(1):223-234.e5. doi: 10.1016/j.jaci.2017.02.035. Epub 2017 Apr 6.
8
Basophils are potent antigen-presenting cells that selectively induce Th2 cells.嗜碱性粒细胞是强有力的抗原呈递细胞，能选择性诱导 Th2 细胞。
Eur J Immunol. 2010 Jul;40(7):1836-42. doi: 10.1002/eji.201040588.
9
Basophils as antigen presenting cells.嗜碱性粒细胞作为抗原提呈细胞。
Trends Immunol. 2010 Feb;31(2):45-8. doi: 10.1016/j.it.2009.12.004. Epub 2010 Jan 8.
10
Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses.胸腺基质淋巴细胞生成素、OX40配体及白细胞介素-25在过敏反应中的作用
Clin Exp Allergy. 2009 Jun;39(6):798-806. doi: 10.1111/j.1365-2222.2009.03241.x. Epub 2009 Apr 7.
引用本文的文献
1
Acquired tick resistance: The trail is hot.获得性蜱抗药性：线索很热。
Parasite Immunol. 2021 May;43(5):e12808. doi: 10.1111/pim.12808. Epub 2020 Dec 15.
2
Fundamental role of dendritic cells in inducing Th2 responses.树突状细胞在诱导Th2反应中的基本作用。
Korean J Intern Med. 2018 May;33(3):483-489. doi: 10.3904/kjim.2016.227. Epub 2018 Mar 5.
3
Transcription factor RBP-J-mediated signalling regulates basophil immunoregulatory function in mouse asthma model.转录因子RBP-J介导的信号传导调节小鼠哮喘模型中嗜碱性粒细胞的免疫调节功能。
Immunology. 2017 Sep;152(1):115-124. doi: 10.1111/imm.12753. Epub 2017 Jul 19.
4
Reference Values for a Panel of Cytokinergic and Regulatory Lymphocyte Subpopulations.一组细胞因子和调节性淋巴细胞亚群的参考值
Immune Netw. 2016 Dec;16(6):344-357. doi: 10.4110/in.2016.16.6.344. Epub 2016 Dec 22.
5
Role of basophils in rheumatoid arthritis (Review).嗜碱性粒细胞在类风湿关节炎中的作用（综述）
Exp Ther Med. 2015 May;9(5):1567-1571. doi: 10.3892/etm.2015.2312. Epub 2015 Feb 24.
6
Emerging role of human basophil biology in health and disease.人类嗜碱性粒细胞生物学在健康和疾病中的新作用。
Curr Allergy Asthma Rep. 2014 Jan;14(1):408. doi: 10.1007/s11882-013-0408-2.
7
State-of-the-art review about basophil research in immunology and allergy: is the time right to treat these cells with the respect they deserve?关于免疫学和过敏领域嗜碱性粒细胞研究的最新综述：现在是给予这些细胞应有的重视的时候了吗？
Blood Transfus. 2012 Apr;10(2):148-64. doi: 10.2450/2011.0020-11. Epub 2011 Dec 21.
本文引用的文献
1
The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling.辅助性 T 细胞 2 型应答半胱氨酸蛋白酶需要树突状细胞-嗜碱性粒细胞通过 ROS 介导的信号转导进行合作。
Nat Immunol. 2010 Jul;11(7):608-17. doi: 10.1038/ni.1883. Epub 2010 May 23.
2
Differentiation of effector CD4 T cell populations (*).效应性 CD4 T 细胞群体的分化（*）。
Annu Rev Immunol. 2010;28:445-89. doi: 10.1146/annurev-immunol-030409-101212.
3
What determines Th2 differentiation, in vitro and in vivo?是什么决定了 Th2 细胞的分化，无论是在体外还是体内？
Immunol Cell Biol. 2010 Mar-Apr;88(3):236-9. doi: 10.1038/icb.2010.2. Epub 2010 Feb 16.
4
Role of basophils in the initiation of Th2 responses.嗜碱性粒细胞在 Th2 反应起始中的作用。
Curr Opin Immunol. 2010 Feb;22(1):73-7. doi: 10.1016/j.coi.2010.01.012. Epub 2010 Feb 9.
5
New paradigms in basophil development, regulation and function.嗜碱性粒细胞的发展、调控和功能的新范式。
Immunol Cell Biol. 2010 Mar-Apr;88(3):275-84. doi: 10.1038/icb.2010.1. Epub 2010 Feb 2.
6
Cutting edge: basophils are transiently recruited into the draining lymph nodes during helminth infection via IL-3, but infection-induced Th2 immunity can develop without basophil lymph node recruitment or IL-3.前沿：在寄生虫感染过程中，通过白细胞介素 3（IL-3），嗜碱性粒细胞会短暂地募集到引流淋巴结中，但在没有嗜碱性粒细胞募集或白细胞介素 3 的情况下，也能诱导产生感染诱导的 Th2 免疫。
J Immunol. 2010 Feb 1;184(3):1143-7. doi: 10.4049/jimmunol.0902447. Epub 2009 Dec 28.
7
Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells.嗜碱性粒细胞通过产生白细胞介素-4以及向CD4+ T细胞呈递肽-主要组织相容性复合体II类复合物，在体内促进辅助性T细胞2型-免疫球蛋白E反应。
Nat Immunol. 2009 Jul;10(7):706-12. doi: 10.1038/ni.1737. Epub 2009 May 24.
8
Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response.嗜碱性粒细胞作为变应原诱导的2型辅助性T细胞应答的抗原呈递细胞发挥作用。
Nat Immunol. 2009 Jul;10(7):713-20. doi: 10.1038/ni.1738. Epub 2009 May 24.
9
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.MHC II类分子依赖性嗜碱性粒细胞与CD4 + T细胞的相互作用促进2型辅助性T细胞（TH2）细胞因子依赖性免疫。
Nat Immunol. 2009 Jul;10(7):697-705. doi: 10.1038/ni.1740. Epub 2009 May 24.
10
Origin of basophils and mast cells.嗜碱性粒细胞和肥大细胞的起源。
Allergol Int. 2009 Mar;58(1):21-8. doi: 10.2332/allergolint.08-RAI-0067. Epub 2009 Jan 25.
Zotero 插件