Takahashi H, Horikoshi T, Jimbow K
Cancer. 1985 Jul 1;56(1):111-23. doi: 10.1002/1097-0142(19850701)56:1<111::aid-cncr2820560118>3.0.co;2-a.
This study characterized the fine structure of melanosomes in melanocytes of the dysplastic nevi in six cases with lentiginous melanocytic dysplasia and one case with epithelioid-cell melanocytic dysplasia, and compared that structure with those of common melanocytic nevi and malignant melanoma. It was found that: fine structural features of melanosomes in dysplastic melanocytes were similar in these two histologic variants, and they were markedly aberrant and quite different from those of common melanocytic nevi; the aberrant melanosomes could be grouped into four subtypes, type 1 melanosomes corresponding to ellipsoidal-lamellar melanosomes, type 2 to spherical-incompletely lamellar melanosomes, type 3 to spherical-granular melanosomes, and type 4 to spherical-vacuolated melanosomes; type 2, 3, and 4 melanosomes were seen in all seven cases although their substructures and numbers varied in individual cases; and these type 2, 3, and 4 melanosomes were not seen in epidermal melanocytes of common melanocytic nevi, but were characteristically seen in superficial spreading melanoma and nodular melanoma. The findings indicated that the fine structural changes in synthesis and melanization of melanosomes are unique to the dysplastic nevi and that they may be helpful in diagnosis of the nevi and may fill the gap of abnormal melanogenesis that exists between common melanocytic nevi and malignant melanoma.
本研究对6例雀斑样黑素细胞发育异常和1例上皮样细胞黑素细胞发育异常的发育异常痣黑素细胞中黑素小体的精细结构进行了表征，并将该结构与普通黑素细胞痣和恶性黑色素瘤的结构进行了比较。结果发现：这两种组织学变体中发育异常黑素细胞的黑素小体精细结构特征相似，且明显异常，与普通黑素细胞痣的结构有显著差异；异常黑素小体可分为四种亚型，1型黑素小体对应椭圆形-板层状黑素小体，2型对应球形-不完全板层状黑素小体，3型对应球形-颗粒状黑素小体，4型对应球形-空泡状黑素小体；在所有7例病例中均可见2型、3型和4型黑素小体，尽管其亚结构和数量在个别病例中有所不同；普通黑素细胞痣的表皮黑素细胞中未见这些2型、3型和4型黑素小体，但在浅表扩散性黑色素瘤和结节性黑色素瘤中可见其特征性表现。这些发现表明，黑素小体合成和黑素化过程中的精细结构变化是发育异常痣所特有的，它们可能有助于痣的诊断，并可能填补普通黑素细胞痣和恶性黑色素瘤之间存在的异常黑素生成的空白。
