Schneider B V, Schnyder U W
Department of Dermatology, University Hospital of Zurich, Switzerland.
Arch Dermatol Res. 1991;283(7):438-44. doi: 10.1007/BF00371779.
In congenital naevocytic naevi (CNN), the ultrastructure of melanosomes has been demonstrated only in a few case reports. In the present study, five defined skin levels were systematically compared by electron microscopy in five giant and seven medium-sized CNN. The ages of the patients ranged from 5 days to 29 years. Six common acquired naevocytic naevi (ANN) served as controls. Melanosomes were classified morphologically into several groups. Epidermal melanosomes were normal in all cases. In 10 of the 12 patients, the morphology and size of dermal melanosomes corresponded well with those in ANN, although in four young children (up to 4-years-old) a few enlarged or atypical forms were found. On the other hand, two new-born babies showed rather different, grossly enlarged dermal melanosomes of various shapes and some unusual internal features. They were seen focally even in lower dermal layers and in naevus cells in subepidermal sweat ducts. We conclude that dermal naevus cells in CNN of new-borns, at least in some cases, may contain melanosomes with unusual morphological variations. This does not necessarily indicate malignant transformation.
在先天性黑素细胞痣（CNN）中，黑素小体的超微结构仅在少数病例报告中有描述。在本研究中，通过电子显微镜对5例巨大型和7例中型CNN的五个明确的皮肤层次进行了系统比较。患者年龄从5天至29岁不等。选取6例常见的后天性黑素细胞痣（ANN）作为对照。黑素小体在形态上被分为几组。所有病例的表皮黑素小体均正常。12例患者中有10例，其真皮黑素小体的形态和大小与后天性黑素细胞痣中的情况相符，不过在4名幼儿（4岁及以下）中发现了一些增大或非典型的形态。另一方面，两名新生儿表现出截然不同的、明显增大的各种形状的真皮黑素小体以及一些不寻常的内部特征。这些黑素小体甚至在真皮深层以及表皮下汗腺导管中的痣细胞中呈局灶性出现。我们得出结论，新生儿CNN中的真皮痣细胞，至少在某些情况下，可能含有形态异常的黑素小体。但这不一定表明发生了恶性转化。
