Department of Bioengineering, University of California, Berkeley, Berkeley, CA 94720, USA.
Curr Opin Chem Biol. 2012 Aug;16(3-4):355-61. doi: 10.1016/j.cbpa.2012.04.009. Epub 2012 May 18.
Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.
最近合成生物学的进展创造了具有增强医疗效果特异性、动态控制、功效和安全性的遗传工具。因此，将这些遗传装置与人类患者接口可能会带来更有效的治疗方法，或者为目前难以解决的疾病提供全新的解决方案。在这里，我们回顾了具有临床潜力的工程电路，并讨论了它们的设计、实施和验证。
