Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan.
Phytother Res. 2013 Mar;27(3):468-71. doi: 10.1002/ptr.4721. Epub 2012 May 21.
The current study was undertaken to explore the antipyretic and anticonvulsant profile of the Polygonatum verticillatum in established pharmacological paradigms. The crude methanol extract of rhizomes (PR) and aerial parts (PA) of the plant were tested in Brewer's-yeast-induced pyrexia and pentylenetetrazole-induced convulsion test. PR and PA both evoked prominent antipyretic activity (p < 0.01) in a dose-dependent manner during all assessment times at the dose of 50, 100, and 200 mg/kg intraperitoneally. The protection elicited by PR (82.20%) at 200 mg/kg was comparable with aspirin (88.48%) as a standard drug at 100 mg/kg. However, PA was less potent, and maximum protection was 64% at 200 mg/kg. Both PR and PA were devoid of any anticonvulsant activity. Our results demonstrated prominent evidence of antipyretic activity of P. verticillatum that is consistent with the folk uses of the plant. In addition from a biodiversity point of view, PA of the plant can also be used as an alternate of PR.
本研究旨在探索黄精在既定药理学模型中的解热和抗惊厥作用。该植物的根茎(PR)和地上部分(PA)的粗甲醇提取物在酿酒酵母诱导发热和戊四氮诱导惊厥试验中进行了测试。PR 和 PA 均以 50、100 和 200 mg/kg 腹膜内给药的剂量依赖性方式在所有评估时间点均表现出明显的解热活性(p<0.01)。PR(200mg/kg)引起的保护作用可与标准药物阿司匹林(100mg/kg)的 88.48%相媲美。然而,PA 的作用较弱,最大保护作用为 200mg/kg 时的 64%。PR 和 PA 均无任何抗惊厥活性。我们的结果表明黄精具有明显的解热活性,这与该植物的民间用途一致。此外,从生物多样性的角度来看,植物的 PA 也可以作为 PR 的替代品。