Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan.
Phytother Res. 2011 Jul;25(7):1024-30. doi: 10.1002/ptr.3369.
Polygonatum verticillatum All. is used traditionally as an analgesic and plant diuretic. The methanol extract of aerial parts of Polygonatum verticillatum (PA) was assessed in various experimental paradigms. The pain threshold in the form of abdominal constriction induced by acetic acid was significantly (p < 0.01) inhibited by PA at test doses (50, 100 and 200 mg/kg). In the formalin test, PA elicited a significant (p < 0.01) analgesic activity in both phases and strongly attenuated the formalin-induced flinching behaviour. The hot plate test was used to evaluate central involvement in the analgesic profile of PA. The PA significantly relieved thermal-induced pain. From a mechanistic point of view, the central antihyperalgesic activity was tested for antagonism with naloxone, but no antagonism was observed. The current investigations suggest that the active constituent(s) in PA has an analgesic profile with predominant peripheral activity which is augmented by an opioid independent central effect. In the diuretic assay, PA (300 and 600 mg/kg) showed mild insignificant diuretic activity. Our study rationalized the traditional use of Polygonatum verticillatum in the treatment of painful conditions.
玉竹传统上被用作镇痛药和植物利尿剂。评价了玉竹地上部分甲醇提取物（PA）在各种实验模型中的作用。用醋酸诱导的腹部收缩形式的痛阈，在测试剂量（50、100 和 200mg/kg）下，明显受到 PA 的抑制（p<0.01）。在福马林试验中，PA 在两个阶段都表现出显著的（p<0.01）镇痛活性，并强烈减弱福马林诱导的退缩行为。热板试验用于评估 PA 的镇痛特征中的中枢参与。PA 可显著缓解热诱导的疼痛。从机制的角度来看，用纳洛酮测试了对中枢抗伤害感受作用的拮抗作用，但未观察到拮抗作用。目前的研究表明，PA 中的活性成分（s）具有以主要外周活性为特征的镇痛特征，这种特征被阿片类药物独立的中枢作用增强。在利尿试验中，PA（300 和 600mg/kg）显示出温和的、无显著的利尿活性。我们的研究合理化了玉竹在治疗疼痛病症中的传统用途。
