Harboe Zitta B, Slotved Hans-Christian, Konradsen Helle B, Kaltoft Margit S
Neisseria and Streptococcus Reference Center, Department of Microbiological Surveillance and Research, Statens Serum Institut, Copenhagen, Denmark.
Open Microbiol J. 2012;6:40-4. doi: 10.2174/1874285801206010040. Epub 2012 May 4.
We present data on pneumococcal carriage before the introduction of the heptavalent-pneumococcal conjugated vaccine (PCV7) in Denmark. In the pre-PCV7 period, the incidence of invasive pneumococcal disease (IPD) among children younger than 5 years was approximately 25 per 100.000 population, with the highest incidence rates observed in children younger than 2 years of age. The study included 437 children aged 12-72 months attending day care centres (DCC) and was conducted during 48 months. In total, 56% (n=247) of children were pneumococcal carriers with the highest prevalence in children aged 12-23 months (69%), the proportion significantly declining with increasing age. PCV7 serotypes accounted for 33%, PCV10 for 34%, and PCV13 for 57% of all carried isolates. The proportion of serotypes included in the three conjugate vaccines was higher among IPD isolates compared to carrier isolates (range 35- 90%). We found that the frequency of carriage was high among Danish pre-school children attending DCC and serotypes were not frequently covered by PCV7 in the pre-PCV7 period.
我们展示了丹麦引入七价肺炎球菌结合疫苗（PCV7）之前的肺炎球菌携带情况数据。在PCV7引入之前的时期，5岁以下儿童侵袭性肺炎球菌疾病（IPD）的发病率约为每10万人口25例，其中2岁以下儿童的发病率最高。该研究纳入了437名12 - 72个月大的日托中心（DCC）儿童，研究持续了48个月。总体而言，56%（n = 247）的儿童为肺炎球菌携带者，其中12 - 23个月大的儿童患病率最高（69%），且该比例随年龄增长显著下降。PCV7血清型占所有携带菌株的33%，PCV10血清型占34%，PCV13血清型占57%。与携带菌株相比，三种结合疫苗中包含的血清型在IPD菌株中的比例更高（范围为35% - 90%）。我们发现，在丹麦上日托中心的学龄前儿童中，携带频率很高，且在PCV7引入之前的时期，PCV7对血清型的覆盖并不常见。
