Laboratório de Biologia Celular e Tecidual, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, 28013-602 Campos dos Goytacazes, RJ, Brazil.
Vet Parasitol. 2012 Oct 26;189(2-4):387-9. doi: 10.1016/j.vetpar.2012.04.030. Epub 2012 Apr 30.
Anthelmintic resistance has emerged globally as a problem amongst nematode of livestock and has been particularly well documented in equine and small ruminants. There are no studies regarding the efficacy of anthelmintics against the hematophagous nematodes in ostriches, Libyostrongylus dentatus; and just a few on L. douglassii. Here the efficacy of albendazole, ivermectin and moxidectin were evaluated against these two species in an ostrich farm in Minas Gerais state, Brazil. The feces were collected on the day of treatment and after 13 days of an oral dose of albendazole (6 mg/kg), or an injected dose (0.2mg/kg) of ivermectin or moxidectin. The fecal egg count reduction test and coprocultures were performed to determine possible resistance against the drugs used. An efficacy of 60% was found for ivermectin, while albendazole and moxidectin were 100% effective. Both worm species appeared to have reduced sensitivity to ivermectin.
抗蠕虫药耐药性已在全球范围内成为家畜线虫的一个问题，并且在马属动物和小反刍动物中得到了很好的记录。关于驱虫剂对鸵鸟血吸性线虫（Libyostrongylus dentatus）和利什曼原虫（L. douglassii）的疗效，目前还没有研究。本研究在巴西米纳斯吉拉斯州的一个鸵鸟养殖场中评估了阿苯达唑、伊维菌素和莫昔克丁对这两种线虫的疗效。在治疗当天和口服阿苯达唑（6mg/kg）或注射伊维菌素或莫昔克丁（0.2mg/kg）后 13 天收集粪便。进行粪便卵计数减少试验和粪培养以确定对所用药物的耐药性。伊维菌素的疗效为 60%，而阿苯达唑和莫昔克丁的疗效为 100%。两种蠕虫都似乎对伊维菌素的敏感性降低。
