利用磁共振成像测量阿尔茨海默病、血管性痴呆、轻度认知障碍和假性痴呆患者海马体积的比较。
Comparison of hippocampal volume measured using magnetic resonance imaging in Alzheimer's disease, vascular dementia, mild cognitive impairment and pseudodementia.
作者信息
Dolek N, Saylisoy S, Ozbabalik D, Adapinar B
机构信息
Department of Radiology, Eskisehir Gynaecology Obstetrics Paediatrics Hospital, Eskisehir, Turkey.
出版信息
J Int Med Res. 2012;40(2):717-25. doi: 10.1177/147323001204000236.
OBJECTIVE
To examine the relationship between different types of dementia and hippocampal volume.
METHODS
Hippocampal volume was measured by magnetic resonance imaging in patients with Alzheimer's disease (n = 22), vascular dementia (n = 14), mild cognitive impairment (n = 12) or pseudodementia (n = 16), and in healthy control subjects (n = 11). The Mini Mental State Examination was used to stratify subjects according to cognitive function.
RESULTS
Hippocampal volume was reduced by 42% in Alzheimer's disease, 21% in vascular dementia, 15% in mild cognitive impairment and 13% in pseudodementia compared with controls. The severity of dementia increased in line with decreasing hippocampal volume.
CONCLUSIONS
Measurement of hippocampal volume may facilitate differentiation between dementia subtypes. There was a relationship between reduced hippocampal volume and the degree of cognitive impairment.
目的
研究不同类型痴呆与海马体积之间的关系。
方法
采用磁共振成像测量阿尔茨海默病患者（n = 22）、血管性痴呆患者（n = 14）、轻度认知障碍患者（n = 12）或假性痴呆患者（n = 16）以及健康对照者（n = 11）的海马体积。使用简易精神状态检查表根据认知功能对受试者进行分层。
结果
与对照组相比，阿尔茨海默病患者的海马体积减少了42%，血管性痴呆患者减少了21%，轻度认知障碍患者减少了15%，假性痴呆患者减少了13%。痴呆的严重程度随着海马体积的减小而增加。
结论
测量海马体积可能有助于区分痴呆亚型。海马体积减小与认知障碍程度之间存在关联。
Zotero 插件