Medicinal Plants Research Center.
Daru. 2011;19(1):74-9.
Stelleropsis antoninae Pobed. (Family: Thymelaeaceae) grows wildly as an herbaceous plant in Iran. Most of the Thymelaeaceous plants contain lignans and neolignans, which have important pharmacologically properties. In the present study, the isolation and identification of the main lignans and neolignans of S. antoninae, which has not been previously reported is described and compared to other species.
Column (CC) and High Performance Liquid Chromatographic (HPLC) methods were used for the isolation and purification, and (1)H-NMR, (13)C-NMR, HMBC, HMQC, H-H COSY and MS were employed for the identification of the compounds isolated from the methanol extract.
From the methanol extract of the aerial parts of S. antoninae four lignans, syringaresinol (1), syringaresinol 4-O-β-D-glucopyranoside (4), syringaresinol 4-O-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside (5), liriodendrin (6), and two neolignans, 5-methoxylariciresinol 4'-O- β-D-glucopyranoside (3) and dehydrodiconiferyl alcohol 4-O-β -D-glucopyranoside (2) were isolated and identified.
The results of this study show that siringaresinol, a well-known bioavtive compound, and its glucosides are the main lignans, and lariciresinol and coniferyl alcohol derivatives are the main neolignans of S. antoninae.
Stelleropsis antoninae Pobed.（野茉莉科）作为一种草本植物在伊朗野生生长。大多数野茉莉科植物含有木脂素和新木脂素，具有重要的药理学特性。在本研究中，描述并比较了之前未报道过的 S. antoninae 的主要木脂素和新木脂素的分离和鉴定，与其他物种进行了比较。
柱层析（CC）和高效液相色谱（HPLC）方法用于分离和纯化，（1）H-NMR、（13）C-NMR、HMBC、HMQC、H-H COSY 和 MS 用于鉴定从甲醇提取物中分离得到的化合物。
从 S. antoninae 地上部分的甲醇提取物中分离得到了四种木脂素，丁香脂素（1）、丁香脂素 4-O-β-D-吡喃葡萄糖苷（4）、丁香脂素 4-O-β-D-吡喃葡萄糖基-（1→6）-β-D-吡喃葡萄糖苷（5）、落叶松脂素（6），以及两种新木脂素，5-甲氧基橄榄树脂素 4'-O-β-D-吡喃葡萄糖苷（3）和去氢二肉桂醇 4-O-β-D-吡喃葡萄糖苷（2）。
本研究结果表明，丁香脂素，一种众所周知的生物活性化合物，及其糖苷是 S. antoninae 的主要木脂素，橄榄树脂素和肉桂醇衍生物是 S. antoninae 的主要新木脂素。
