Exp Dermatol. 2012 Jun;21(6):461-3. doi: 10.1111/j.1600-0625.2012.01489.x.
Malignant Sezary cells express the natural killer (NK) receptors KIR3DL2 (CD158k) and Nkp46 and may co-express activating killer immunoglobulin-like receptors (KIR) that may participate to neoplastic T-cell activation through the JNK pathway. Little is known regarding NK receptor expression in other cutaneous T-cell lymphomas. We studied the expression of KIR and natural cytotoxicity receptor (NCR) transcripts, and KIR3DL1/2 at the protein level, in 16 skin biopsies from 10 patients with transformed mycosis fungoides (tMF). Some KIR and NCR transcripts were found in all cases, with various repertoires. Two to nine different KIR receptors were expressed in a single biopsy. Among them, KIR3DL2 was the most frequent, with the highest level of expression in quantitative analyses and correlated with in situ protein expression, while phosphorylated JNK was never detected. Among NCR, NKp46 was expressed in all investigated cases. The role of KIR3DL2 and NKp46 in tMF oncogenesis remains to be studied.
恶性赛扎里细胞表达自然杀伤 (NK) 受体 KIR3DL2（CD158k）和 Nkp46，并且可能共同表达激活的杀伤免疫球蛋白样受体 (KIR)，这些受体可能通过 JNK 途径参与肿瘤 T 细胞的激活。关于其他皮肤 T 细胞淋巴瘤中 NK 受体的表达知之甚少。我们研究了 10 例转化蕈样真菌病 (tMF) 患者的 16 个皮肤活检样本中 KIR 和自然细胞毒性受体 (NCR) 转录本以及 KIR3DL1/2 的蛋白表达。在所有病例中均发现了某些 KIR 和 NCR 转录本，其具有不同的组成。在单个活检中表达了 2 到 9 种不同的 KIR 受体。其中，KIR3DL2 最为常见，其在定量分析中的表达水平最高，并且与原位蛋白表达相关，而磷酸化 JNK 从未检测到。在 NCR 中，NKp46 在所有研究病例中均有表达。KIR3DL2 和 NKp46 在 tMF 肿瘤发生中的作用仍有待研究。
