Medical Research Council Lifecourse Epidemiology Unit, Southampton General Hospital, Southampton, United Kingdom.
Am J Clin Nutr. 2012 Jul;96(1):57-63. doi: 10.3945/ajcn.112.037473. Epub 2012 May 23.
Low vitamin D status has been linked to adiposity, but little is known of the effects of low status in pregnancy on offspring body composition.
The objective was to determine how maternal vitamin D status relates to lean and fat mass of the offspring.
The offspring of 977 pregnant women, who had serum 25-hydroxyvitamin D [25(OH)D] measured at 34 wk gestation, were followed up within 3 wk of birth and at 4 and 6 y of age for dual-energy X-ray absorptiometry assessment of lean and fat mass.
The median maternal serum 25(OH)D concentration was 62 nmol/L (IQR: 43-89 nmol/L); 35% of the women studied had values <50 nmol/L. Lower vitamin D status was associated with lower fat mass in the offspring at birth but with greater fat mass at ages 4 and 6 y. It was not associated with lean mass at any of the ages studied. The opposing associations seen between maternal 25(OH)D (SDs) and fat mass (SDs) in the offspring at birth and at age 6 y were robust to adjustment for a range of confounding factors, including maternal BMI and weight gain in pregnancy [β (95% CI): 0.08 (0.02, 0.15) and -0.10 (-0.17, -0.02), respectively]. The key independent predictors of higher maternal vitamin D status were season of assessment and use of vitamin D supplements.
Lower maternal vitamin D status may be linked to programmed differences in offspring fat mass. The findings require replication but add to a growing evidence base for a role of vitamin D in the origins of adiposity.
维生素 D 水平低下与肥胖有关，但人们对妊娠期间维生素 D 水平低下对后代身体成分的影响知之甚少。
本研究旨在确定母体维生素 D 状态与后代瘦体重和脂肪量的关系。
对 977 名孕妇的后代进行了研究，这些孕妇在妊娠 34 周时检测了血清 25-羟维生素 D [25(OH)D]，并在出生后 3 周内以及 4 岁和 6 岁时进行了双能 X 射线吸收法评估瘦体重和脂肪量。
母体血清 25(OH)D 浓度中位数为 62 nmol/L（四分位距：43-89 nmol/L）；35%的研究对象血清 25(OH)D 值<50 nmol/L。较低的维生素 D 状态与出生时后代的脂肪量较低相关，但与 4 岁和 6 岁时的脂肪量较高相关。它与任何研究年龄的瘦体重均无相关性。母体 25(OH)D（标准差）与出生时和 6 岁时后代脂肪量（标准差）之间的相反关系在调整了一系列混杂因素后仍然稳健，包括母体 BMI 和妊娠期间体重增加[β（95%CI）：0.08（0.02，0.15）和-0.10（-0.17，-0.02）]。母体维生素 D 状态较高的主要独立预测因素为评估季节和维生素 D 补充剂的使用。
母体维生素 D 水平较低可能与后代脂肪量的程序性差异有关。这些发现需要进一步证实，但增加了维生素 D 在肥胖起源中的作用的证据基础。
