Medical Research Council Lifecourse Epidemiology Unit (N.C.H., R.J.M., A.A.S., G.N., S.M.R., K.M.G., H.M.I., C.C.), University of Southampton, Southampton SO16 6YD, United Kingdom; National Institute for Health Research Southampton Biomedical Research Centre (N.C.H., K.M.G., C.C.), University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom; Paediatric Endocrinology (R.J.M., J.H.D.), University Hospital Southampton National Health Service Foundation Trust, Southampton SO16 6YD, United Kingdom; and National Institute for Health Research Musculoskeletal Biomedical Research Unit (M.K.J., C.C.), University of Oxford, Nuffield Orthopedic Centre, Headington, Oxford OX3 7HE, United Kingdom.
J Clin Endocrinol Metab. 2014 Jan;99(1):330-7. doi: 10.1210/jc.2013-3241. Epub 2013 Dec 20.
Maternal 25-hydroxyvitamin D [25(OH)D] status in pregnancy has been associated with offspring bone development and adiposity. Vitamin D has also been implicated in postnatal muscle function, but little is known about a role for antenatal 25(OH)D exposure in programming muscle development.
We investigated the associations between maternal plasma 25(OH)D status at 34 weeks of gestation and offspring lean mass and muscle strength at 4 years of age.
We studied a prospective UK population-based mother-offspring cohort: the Southampton Women's Survey (SWS).
Initially, 12,583 nonpregnant women were recruited into the SWS, of whom 3159 had singleton pregnancies; 678 mother-child pairs were included in this analysis.
At 4 years of age, offspring assessments included hand grip strength and whole-body dual-energy x-ray absorptiometry, yielding lean mass and percent lean mass. Physical activity was assessed by 7-day accelerometry in a subset of children (n=326).
The maternal serum 25(OH)D concentration in pregnancy was positively associated with offspring height-adjusted hand grip strength (β=0.10 SD/SD, P=.013), which persisted after adjustment for maternal confounding factors, duration of breastfeeding, and child's physical activity at 4 years (β=0.13 SD/SD, P=.014). Maternal 25(OH)D was also positively associated with offspring percent lean mass (β=0.11 SD/SD, P=.006), but not total lean mass (β=0.06 SD/SD, P=.15). However, this association did not persist after adjustment for confounding factors (β=0.09 SD/SD, P=.11).
This observational study suggests that intrauterine exposure to 25(OH)D during late pregnancy might influence offspring muscle development through an effect primarily on muscle strength rather than on muscle mass.
孕妇 25-羟维生素 D [25(OH)D] 状况与后代骨骼发育和肥胖有关。维生素 D 也与产后肌肉功能有关，但对于产前 25(OH)D 暴露在肌肉发育中的编程作用知之甚少。
我们研究了妊娠 34 周时母体血浆 25(OH)D 状况与 4 岁时后代瘦体重和肌肉力量之间的关系。
我们研究了一个英国前瞻性基于人群的母婴队列：南安普顿女性调查 (SWS)。
最初，有 12583 名未怀孕的女性被招募进入 SWS，其中 3159 名女性怀有单胎妊娠；在这项分析中，有 678 对母婴对被纳入。
在 4 岁时，对后代进行了手握力和全身双能 X 射线吸收测定，得出瘦体重和瘦体重百分比。在一小部分儿童中（n=326）通过 7 天加速度计评估了体力活动。
妊娠期间母体血清 25(OH)D 浓度与后代身高调整后的手握力呈正相关（β=0.10 SD/SD，P=.013），调整母体混杂因素、母乳喂养持续时间和 4 岁时儿童体力活动后仍然存在（β=0.13 SD/SD，P=.014）。母体 25(OH)D 也与后代瘦体重百分比呈正相关（β=0.11 SD/SD，P=.006），但与总瘦体重无关（β=0.06 SD/SD，P=.15）。然而，在调整混杂因素后，这种相关性不再存在（β=0.09 SD/SD，P=.11）。
这项观察性研究表明，妊娠晚期宫内暴露于 25(OH)D 可能通过主要影响肌肉力量而不是肌肉质量来影响后代的肌肉发育。
