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本文引用的文献

1
A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution.一项 ChIP-seq 定义的维生素 D 受体结合的全基因组图谱：与疾病和进化的关联。
Genome Res. 2010 Oct;20(10):1352-60. doi: 10.1101/gr.107920.110. Epub 2010 Aug 24.
2
The vitamin D receptor gene BsmI polymorphism is not associated with anthropometric and biochemical parameters describing metabolic syndrome in postmenopausal women.维生素D受体基因BsmI多态性与描述绝经后女性代谢综合征的人体测量学和生化参数无关。
Gynecol Endocrinol. 2008 Sep;24(9):514-8. doi: 10.1080/09513590802302985.
3
Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome.维生素D受体BsmI和FokI基因多态性与描述代谢综合征的人体测量学和生化参数之间的关系。
Aging Male. 2008 Sep;11(3):134-9. doi: 10.1080/13685530802273426.
4
Vitamin D(3) in fat tissue.脂肪组织中的维生素D(3)
Endocrine. 2008 Feb;33(1):90-4. doi: 10.1007/s12020-008-9051-4. Epub 2008 Mar 13.
5
Vitamin D and adipogenesis: new molecular insights.维生素D与脂肪生成：新的分子见解
Nutr Rev. 2008 Jan;66(1):40-6. doi: 10.1111/j.1753-4887.2007.00004.x.
6
PLINK: a tool set for whole-genome association and population-based linkage analyses.PLINK：一个用于全基因组关联分析和基于群体的连锁分析的工具集。
Am J Hum Genet. 2007 Sep;81(3):559-75. doi: 10.1086/519795. Epub 2007 Jul 25.
7
Vitamin D deficiency.维生素D缺乏症
N Engl J Med. 2007 Jul 19;357(3):266-81. doi: 10.1056/NEJMra070553.
8
Genetic epidemiology of obesity.肥胖的遗传流行病学
Epidemiol Rev. 2007;29:49-61. doi: 10.1093/epirev/mxm004. Epub 2007 Jun 12.
9
Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity.1958年英国出生队列中的维生素D状况与葡萄糖稳态：肥胖的作用。
Diabetes Care. 2006 Oct;29(10):2244-6. doi: 10.2337/dc06-0946.
10
The human obesity gene map: the 2005 update.人类肥胖基因图谱：2005年更新版。
Obesity (Silver Spring). 2006 Apr;14(4):529-644. doi: 10.1038/oby.2006.71.

维生素 D 受体基因多态性与肥胖表型有关。

Vitamin D receptor gene polymorphisms are associated with adiposity phenotypes.

机构信息

Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.

出版信息

Am J Clin Nutr. 2011 Jan;93(1):5-10. doi: 10.3945/ajcn.2010.29986. Epub 2010 Nov 3.

DOI:10.3945/ajcn.2010.29986
PMID:21048058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3001595/
Abstract

BACKGROUND

Emerging data suggest a role for the vitamin D receptor (VDR) in lipogenesis and adipocyte differentiation.

OBJECTIVE

Our objective was to evaluate the association of VDR gene variants and adiposity phenotypes in an epidemiologic study.

DESIGN

In a sample of 1773 healthy female adults recruited from western New York, we tested for the association of 14 VDR single nucleotide polymorphisms (SNPs) with the following 3 adiposity phenotypes: body mass index (in kg/m²), waist circumference (in cm), and abdominal height (in cm). We examined age, education, total energy intake, smoking status, alcohol intake, and menopausal status as potential covariates.

RESULTS

One SNP, rs3782905, remained associated with all 3 adiposity phenotypes after multiple-testing correction (Bonferroni-adjusted P = 0.004). The mean waist circumference for women with the rs3782905 homozygous rare genotype was 4.4 cm larger than for women with the common homozygous genotype. Two other VDR SNPs were associated with waist circumference and abdominal height, but the associations did not survive multiple-testing correction. Adjustment for covariates did not influence the results.

CONCLUSION

The study results and the biological activity of VDR in adipocyte differentiation suggest that 3' VDR variants may play a role in adiposity phenotypes.

摘要

背景

新出现的数据表明维生素 D 受体 (VDR) 在脂肪生成和脂肪细胞分化中起作用。

目的

我们的目的是在一项流行病学研究中评估 VDR 基因变异与肥胖表型的关系。

设计

在从纽约西部招募的 1773 名健康成年女性样本中，我们检测了 14 个 VDR 单核苷酸多态性 (SNP) 与以下 3 种肥胖表型的关联：体重指数 (kg/m²)、腰围 (cm) 和腹高 (cm)。我们将年龄、教育程度、总能量摄入、吸烟状况、饮酒状况和绝经状况作为潜在的协变量进行了检验。

结果

在经过多次检验校正 (Bonferroni 调整后的 P = 0.004) 后，只有一个 SNP(rs3782905) 与所有 3 种肥胖表型仍然相关。rs3782905 纯合罕见基因型女性的平均腰围比常见纯合基因型女性大 4.4cm。另外 2 个 VDR SNP 与腰围和腹高有关，但这些关联在多次检验校正后并不成立。协变量的调整并没有影响结果。

结论

研究结果以及 VDR 在脂肪细胞分化中的生物学活性表明，3' VDR 变异可能在肥胖表型中起作用。