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槲寄生的细胞毒性成分。

Cytotoxic constituents of Viscum coloratum.

机构信息

Department of Pharmaceutical Analysis, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China.

出版信息

Z Naturforsch C J Biosci. 2012 Mar-Apr;67(3-4):129-34.

PMID:22624328
Abstract

Phytochemical studies on Viscum coloratum have resulted in the isolation of nineteen compounds. The structures of the isolated compounds were identified on the basis of 1D, 2D NMR and HR-ESI-Q-TOF-MS. Pachypodol (4) and ombuine (6) were characterized in the family Loranthaceae for the first time. 1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one (8) and 5-hydroxy-3,7,3'-trimethoxyflavone-4'-O-beta-D-glucoside (13) were two new natural compounds, which exhibited cytotoxic activities against four human tumour cell lines (HeLa, SGC-7901, MCF-7, and U251).

摘要

从槲寄生中分离得到了 19 种化合物。通过 1D、2D NMR 和 HR-ESI-Q-TOF-MS 鉴定了分离化合物的结构。在桑寄生科中首次发现了 pachypodol(4)和 ombuine(6)。1,7-双(4-羟基苯基)-1,4-庚二烯-3-酮(8)和 5-羟基-3,7,3'-三甲氧基黄酮-4'-O-β-D-葡萄糖苷(13)是两种新的天然化合物,对四种人肿瘤细胞系(HeLa、SGC-7901、MCF-7 和 U251)具有细胞毒性活性。

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