Laser Suite, Mater Private Hospital, Dublin, Ireland.
J Cataract Refract Surg. 2012 Jun;38(6):1058-64. doi: 10.1016/j.jcrs.2012.01.028.
To evaluate the effects of laser in situ keratomileusis (LASIK) and laser-assisted subepithelial keratectomy (LASEK) on dry-eye disease markers including tear osmolarity, Schirmer testing, and the ocular surface disease index (OSDI).
Laser Suite, Mater Private Hospital, Dublin, Ireland.
Prospective controlled cross-sectional observation study.
In a single center, consecutive eyes that had LASIK or LASEK had dry-eye disease markers assessed preoperatively and 3, 6, and 12 months postoperatively.
In LASIK eyes (n = 50), the mean tear osmolarity was significantly elevated (by 2.8%) at 12 months (P=.009, Student t test). The mean Schirmer test values were not significantly altered postoperatively in either group. The mean OSDI was maximum in LASIK eyes at 3 months (mean follow-up 7.2 months ± 8.2 [SD]) and in LASEK eyes (n = 35) preoperatively (mean follow-up 9.1 ± 9.7 months).
There were no significant differences in dry-eye disease markers or tear osmolarity between LASIK and LASEK patients at any stage after surgery up to 1 year. Although tear osmolarity remains one of the highest predictive tests of dry eye, it is complementary with other diagnostic criteria in the context of dry eye after refractive surgery.
评估激光原位角膜磨镶术（LASIK）和激光辅助上皮下角膜切除术（LASEK）对干眼疾病标志物的影响，包括泪液渗透压、泪液分泌试验和眼表面疾病指数（OSDI）。
都柏林 Mater Private Hospital 的激光套房。
前瞻性对照横断面观察研究。
在一个单中心，连续对接受 LASIK 或 LASEK 的眼进行术前和术后 3、6 和 12 个月的干眼疾病标志物评估。
在 LASIK 眼（n=50）中，术后 12 个月泪液渗透压显著升高（升高 2.8%）（P=.009，学生 t 检验）。两组术后的平均 Schirmer 试验值均无明显改变。LASIK 眼的 OSDI 在术后 3 个月（平均随访 7.2 个月±8.2[SD]）和 LASEK 眼（n=35）术前（平均随访 9.1±9.7 个月）最大。
在术后 1 年内的任何阶段，LASIK 和 LASEK 患者的干眼疾病标志物或泪液渗透压均无显著差异。虽然泪液渗透压仍然是干眼的最高预测性测试之一，但在屈光手术后干眼的情况下，它与其他诊断标准是互补的。
