Zanardo V, Giacobbo F, Zambon P, Trevisanuto D, Griffith P, Grella P, Zacchello G
Department of Pediatrics, Padova University, Italy.
J Perinat Med. 1990;18(4):283-8. doi: 10.1515/jpme.1990.18.4.283.
Creatinine clearance and renal sodium excretion were measured consecutively in three groups of 12 premature infants (gestational age less than or equal to 35 weeks) whose mothers had received either steroids or aminophylline, or steroids and aminophylline before delivery. We found no significant differences for plasma and urine creatinine and its clearance in the groups considered. The steroid group presented urine osmolality and urine/plasma osmolality ratio significantly higher than among the other groups. Furthermore, urine potassium excretion increased, and urine sodium and sodium fractional excretion were reduced. Aminophylline exposure did not interfere with the hydrosaline equilibrium nor with renal function of the preterms at birth. Our results reconfirm that corticosteroid hormones play an important part in the fetal renal maturation process, inducing a precocious maturation of the tubular Na(+)-K+ ATPase enzymatic system, that is substantially unmodified by aminophylline exposure. However, due to the prolonged half-life of aminophylline in prematures, it seems reasonable to verify the coupling of tubular and glomerular functions also in the following days of life.
对三组各12名早产婴儿（胎龄小于或等于35周）连续测量肌酐清除率和肾钠排泄，这些婴儿的母亲在分娩前接受了类固醇、氨茶碱或类固醇加氨茶碱治疗。在所研究的组中，我们发现血浆和尿液肌酐及其清除率没有显著差异。类固醇组的尿渗透压和尿/血浆渗透压比值显著高于其他组。此外，尿钾排泄增加，尿钠和钠分数排泄减少。氨茶碱暴露对出生时早产儿的水盐平衡和肾功能没有干扰。我们的结果再次证实，皮质类固醇激素在胎儿肾脏成熟过程中起重要作用，诱导肾小管钠钾ATP酶系统早熟，而氨茶碱暴露对此基本无影响。然而，由于氨茶碱在早产儿体内的半衰期延长，在出生后的几天内也验证肾小管和肾小球功能的耦合似乎是合理的。
