Harkavy K L, Scanlon J W, Jose P
Biol Neonate. 1979;35(3-4):126-30. doi: 10.1159/000241163.
The effects of aminophylline on renal function in 10 premature infants with idiopathic apnea are evaluated. The percent increases in creatinine clearance (128 +/- 339%, mean +/- SD) and sodium clearance (196 +/- 304%, mean +/- SD) are variable while the percent increase in fractional sodium excretion (69 +/- 109%, mean +/- SD) is significant. This effect is postulated to be at the proximal tubule and may be modified by the effects of postnatal age and infusion of albumin. Gestational age, birth weight, heart disease, water and sodium intake and ventilatory support did not appear to influence the results. Hyponatremia is a potential consequence of theophylline therapy for apnea.
评估了氨茶碱对10例特发性呼吸暂停早产儿肾功能的影响。肌酐清除率（平均±标准差为128±339%）和钠清除率（平均±标准差为196±304%）的增加百分比变化不定，而钠排泄分数增加百分比（平均±标准差为69±109%）则有显著意义。推测这种作用发生在近端小管，且可能受出生后年龄和白蛋白输注的影响而改变。胎龄、出生体重、心脏病、水和钠摄入量以及通气支持似乎并未影响结果。低钠血症是茶碱治疗呼吸暂停的一个潜在后果。
