Liu Ke, Qin Cheng-Kun, Wang Zhi-Yi, Liu Su-Xia, Cui Xian-Ping, Zhang Dong-Yuan
Department of Hepatobiliary, Provincial Hospital affiliated to Shandong University, Jinan, China.
Asian Pac J Cancer Prev. 2012;13(3):847-50. doi: 10.7314/apjcp.2012.13.3.847.
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 or TIPE) is a recently identified protein considered to be associated with carcinogenesis. To investigate its expression pattern in pancreatic cancer patients and to analyse its correlation with clinicopathological significance and the expression levels of epithelial growth factor receptor (EGFR), immunohistochemistry was performed to detect the TNFAIP8 and EGFR proteins in pancreatic cancers, pancreatitis tissues, and healthy controls. The results showed stronger staining of TNFAIP8 protein in pancreatic cancer tissues compared with normal pancreas tissue. Furthermore, in 56 patients with pancreatic cancer, the expression levels of TNFAIP8 in patients with low tumor stage was higher than that with high tumor stage, and correlated with tumor staging and lymph node metastasis (P<0.05). Furthermore, TNFAIP8 expression positively correlated with EGFR levels (r=0.671135, P<0.05). These results indicate that TNFAIP8 may play important roles in the progression of pancreatic cancer.
肿瘤坏死因子（TNF）-α诱导蛋白8（TNFAIP8或TIPE）是一种最近发现的被认为与致癌作用相关的蛋白质。为了研究其在胰腺癌患者中的表达模式，并分析其与临床病理意义以及上皮生长因子受体（EGFR）表达水平的相关性，采用免疫组织化学方法检测胰腺癌、胰腺炎组织及健康对照中TNFAIP8和EGFR蛋白。结果显示，与正常胰腺组织相比，胰腺癌组织中TNFAIP8蛋白染色更强。此外，在56例胰腺癌患者中，肿瘤分期低的患者TNFAIP8表达水平高于肿瘤分期高的患者，且与肿瘤分期和淋巴结转移相关（P<0.05）。此外，TNFAIP8表达与EGFR水平呈正相关（r=0.671135，P<0.05）。这些结果表明，TNFAIP8可能在胰腺癌进展中起重要作用。
