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激素替代疗法:51岁丹麦女性的使用模式。

Hormone replacement therapy: use patterns in 51-year-old Danish women.

作者信息

Køster A

机构信息

Glostrup Population Studies, Glostrup Hospital, University of Copenhagen, Denmark.

出版信息

Maturitas. 1990 Nov;12(4):345-56. doi: 10.1016/0378-5122(90)90014-w.

Abstract

A survey based on a postal questionnaire sent to all women born in 1936 living in four Copenhagen suburbs (n = 597, response rate = 88%) revealed an overall prevalence of hormone replacement therapy (HRT) use of 22% and a cumulative incidence of 37%. This paper describes the use of HRT in this population and the patterns of exposure to treatment. Our results indicate that the use of HRT, particularly combined oestrogen-progestogen therapy, is increasing and is being initiated during the pre-menopause. Climacteric complaints were the main reason for starting treatment; only a minority of the respondents were motivated by prophylactic considerations. Forty percent discontinued treatment, the majority stating that they had done so because of unpleasant adverse reactions or lack of effect.

摘要

一项基于邮寄问卷调查的研究,调查对象为居住在哥本哈根四个郊区、出生于1936年的所有女性(n = 597,回复率 = 88%),结果显示激素替代疗法(HRT)的总体使用率为22%,累积发病率为37%。本文描述了该人群中HRT的使用情况及治疗暴露模式。我们的结果表明,HRT的使用,尤其是联合雌激素 - 孕激素疗法的使用正在增加,且在绝经前就开始使用。更年期症状是开始治疗的主要原因;只有少数受访者是出于预防考虑。40%的人停止了治疗,大多数人表示停药是因为出现了令人不适的不良反应或治疗无效。

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