Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, China.
Acta Ophthalmol. 2013 Sep;91(6):521-5. doi: 10.1111/j.1755-3768.2012.02454.x. Epub 2012 May 25.
To examine size and frequency of parapapillary atrophy (beta zone) in patients with intrasellar or perisellar tumours and a glaucoma-like appearance of the intrapapillary optic disc region.
Thirty-four Chinese subjects with intrasellar or perisellar tumours and a glaucoma-like appearance of the intrapapillary optic disc region and 129 age-matched subjects randomly selected from the population-based Beijing Eye Study were enrolled. Beta zone was measured on fundus photographs. Size and location of the tumours were assessed on neuroradiological images.
Beta zone was significantly more common (79 ± 7% versus 46 ± 4%; p = 0.001), and it was significantly larger in the tumour group than in the control group (circumferential extent: 135 ± 99 versus 57 ± 72; p < 0.001; relative area: 1856 ± 1923 versus 759 ± 1390; p = 0.002). The width of the intracerebral tumours was significantly associated with the circumferential extent of beta zone (r = 0.36, p = 0.039) and with the area of beta zone (r = 0.37, p = 0.032). Tumour width, height and depth were significantly (p = 0.001; p = 0.012; and p < 0.001, respectively) larger in the group of patients with beta zone than in the subgroup of patients without beta zone of parapapillary atrophy.
Patients with large intrasellar or perisellar tumours and a glaucoma-like appearance of the intrapapillary region as compared with a population-based control group had a significantly larger and more frequently occurring beta zone of parapapillary atrophy. It suggests that large parasellar or suprasellar tumours can be associated with typical glaucomatous abnormalities in the parapapillary and intrapapillary region of the optic nerve head. It may give hints for the pathogenesis of glaucomatous optic neuropathy.
研究鞍内或鞍旁肿瘤患者及视神经乳头内盘沿区青光眼样外观患者视盘旁视网膜神经纤维层（β区）的萎缩大小和频率。
纳入 34 例鞍内或鞍旁肿瘤患者及视神经乳头内盘沿区青光眼样外观患者及 129 例从人群中随机选择的北京眼研究的年龄匹配对照者。眼底照片测量β区。神经影像学图像评估肿瘤大小和位置。
β区更常见（79±7%比 46±4%；p=0.001），且肿瘤组明显大于对照组（周向范围：135±99比 57±72；p<0.001；相对面积：1856±1923比 759±1390；p=0.002）。颅内肿瘤的宽度与β区周向范围（r=0.36，p=0.039）和β区面积（r=0.37，p=0.032）显著相关。肿瘤宽度、高度和深度在有β区的患者组中明显大于无β区的患者亚组（p=0.001；p=0.012；和 p<0.001）。
与基于人群的对照组相比，有较大的鞍内或鞍旁肿瘤及视神经乳头内盘沿区青光眼样外观的患者有明显更大和更频繁发生的视盘旁视网膜神经纤维层（β区）萎缩。这表明大型鞍旁或鞍上肿瘤可能与视神经乳头旁和盘沿区典型的青光眼异常有关。它可能提示青光眼性视神经病变的发病机制。
