MacGregor J T, Schlegel R, Wehr C M, Alperin P, Ames B N
Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720.
Proc Natl Acad Sci U S A. 1990 Dec;87(24):9962-5. doi: 10.1073/pnas.87.24.9962.
Folate deficiency in Swiss mice increased the incidence of micronuclei in peripheral blood erythrocytes, indicating increased chromosomal damage in nucleated erythrocyte precursors. Caffeine enhanced the incidence of micronuclei in blood and bone marrow by up to 5-fold in folate-deficient mice at doses that did not significantly alter the micronucleus frequency in the presence of adequate dietary folate. The lower dose of caffeine used in this study (75 mg/kg) approaches doses received by humans who consume large amounts of caffeinated beverages. Since folate deficiency and caffeine consumption are highly prevalent in the human population, the potential for a similar interaction in man should be evaluated.
瑞士小鼠体内的叶酸缺乏增加了外周血红细胞中微核的发生率，表明有核红细胞前体中的染色体损伤增加。在饮食中叶酸充足时，咖啡因剂量不会显著改变微核频率，但在叶酸缺乏的小鼠中，咖啡因使血液和骨髓中微核的发生率提高了5倍。本研究中使用的较低剂量咖啡因（75毫克/千克）接近大量饮用含咖啡因饮料的人摄入的剂量。鉴于叶酸缺乏和咖啡因摄入在人群中非常普遍，应该评估人类中类似相互作用的可能性。
