组成型脆性位点与癌症
Constitutive fragile sites and cancer.
作者信息
Yunis J J, Soreng A L
出版信息
Science. 1984 Dec 7;226(4679):1199-204. doi: 10.1126/science.6239375.
PMID:6239375
Abstract
Breaks were observed at 51 sites in homologous chromosomes in lymphocytes from ten humans and two great apes when cells were deprived of thymidine. The incidence of breaks was enhanced by caffeine, a substance that inhibits DNA repair in replicating cells. The locations of 20 sites were correlated with breakpoints that have been related to human malignancy.
摘要
当细胞缺乏胸苷时，在来自10名人类和2只大猩猩的淋巴细胞的同源染色体中的51个位点观察到了断裂。咖啡因可提高断裂的发生率，咖啡因是一种抑制复制细胞中DNA修复的物质。20个位点的位置与已与人类恶性肿瘤相关的断点相关。
Zotero 插件