促肾上腺皮质激素诱导的大鼠痛觉过敏
ACTH-induced hyperalgesia in rats.
作者信息
Bertolini A, Poggioli R, Ferrari W
出版信息
Experientia. 1979 Sep 15;35(9):1216-7. doi: 10.1007/BF01963298.
PMID:226398
Abstract
The injection of ACTH 1--24 into the cerebral ventricles in rats markedly reduces the reaction time in the hot-plate test and the nociception threshold in the tail-stimulation test. Morphine antagonizes and naloxone potentiates this hyperalgesic effect of ACTH. It is proposed that ACTH peptides play a physiological role in nociception.
摘要
向大鼠脑室内注射促肾上腺皮质激素1-24可显著缩短热板试验中的反应时间，并降低尾刺激试验中的痛觉阈值。吗啡可拮抗促肾上腺皮质激素的这种痛觉过敏作用，而纳洛酮则可增强其作用。有人提出促肾上腺皮质激素肽在痛觉感受中发挥生理作用。
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