促肾上腺皮质激素在大鼠中诱发的行为综合征可通过钙通道阻滞来预防。

The behavioral syndrome induced by adreno corticotropic hormone in rats is prevented by Ca++ channel blockade.

作者信息

Poggioli R, Rasori E, Bertolini A

机构信息

Istituto di Farmacologia, Università di Modena, Italy.

出版信息

J Endocrinol Invest. 1993 Feb;16(2):83-6. doi: 10.1007/BF03347653.

DOI:10.1007/BF03347653

PMID:8463553

Abstract

The most typical signs (stretchings, yawnings, penile erections, excessive grooming) of the behavioral syndrome induced in rats by the intracerebroventricular administration of ACTH- (1-24) (4 micrograms/rat) were dose-dependently antagonized by the intraperitoneal injection of the selective Ca++ channel inhibitor, nicardipine (dose range: 0.1-1 mg/kg). These data suggest that the influx of Ca++ into target neurons is a step of key importance for the occurrence of ACTH-induced behavioral signs, and that Ca++ may play the role of second intracellular messenger for the behavioral effects of melanocortins.

摘要

通过脑室内注射促肾上腺皮质激素（1 - 24）（4微克/只大鼠）诱导大鼠产生行为综合征的最典型体征（伸展、打哈欠、阴茎勃起、过度梳理毛发），腹腔注射选择性钙离子通道抑制剂尼卡地平（剂量范围：0.1 - 1毫克/千克）可呈剂量依赖性地拮抗这些体征。这些数据表明，钙离子流入靶神经元是促肾上腺皮质激素诱导行为体征发生的关键步骤，并且钙离子可能作为黑皮质素行为效应的细胞内第二信使发挥作用。