孕妇血浆尿皮质素水平作为早产的生物标志物：伊拉克苏莱曼尼亚市的一项前瞻性队列研究
Maternal plasma urocortin level as a biomarker of preterm birth: a prospective cohort study in Sulaimaniyah city in Iraq.
作者信息
Nasir Sallama Kamel
机构信息
Department of Clinical Medical Sciences, College of Medicine, University of Sulaimani, Sulaimaniyah, Iraq.
Sulaimani Maternity Teaching Hospital, Sulaimani Directorate of Health, Sulaimaniyah, Iraq.
出版信息
J Int Med Res. 2025 Jan;53(1):3000605241311438. doi: 10.1177/03000605241311438.
OBJECTIVE
To evaluate the value of the urocortin (UCN) level to predict preterm delivery in women with threatened preterm labour.
METHODS
This prospective cohort study included 96 women with a singleton pregnancy between 28 and 34 weeks of gestation who were admitted with threatened preterm labour. The participants were monitored until delivery. The UCN level was compared between those with preterm and with full-term deliveries.
RESULTS
The mean UCN level was higher for preterm deliveries (96 ± 24.34 pg/mL) than for full-term deliveries (62.62 ± 23.63 pg/mL). A UCN cutoff level of 92 pg/mL had 20% sensitivity, 100% specificity, 100% positive predictive value, and 10% negative predictive value. Thus, 17.7% of women had a UCN level ≥ 92 pg/mL, and all delivered preterm. Among the 82.3% of women who had a UCN level < 92 pg/mL, 88.6% delivered preterm, and 11.4% delivered at full term. Moreover, 88.2% of women who had a UCN level ≥ 92 pg/mL delivered within 7 days and only 11.8% delivered after 7 days. However, 58.2% of women with a UCN level < 92 pg/mL delivered within 7 days and 41.8% delivered after 7 days.
CONCLUSION
A UCN cutoff level of ≥92 pg/mL predicts preterm delivery within 7 days of admission.
目的
评估尿皮质素（UCN）水平对预测先兆早产女性发生早产的价值。
方法
这项前瞻性队列研究纳入了96名单胎妊娠、孕28至34周且因先兆早产入院的女性。对参与者进行监测直至分娩。比较早产和足月分娩者的UCN水平。
结果
早产者的平均UCN水平（96±24.34 pg/mL）高于足月分娩者（62.62±23.63 pg/mL）。UCN临界值为92 pg/mL时，敏感性为20%，特异性为100%，阳性预测值为100%，阴性预测值为10%。因此，17.7%的女性UCN水平≥92 pg/mL，且均发生早产。在UCN水平<92 pg/mL的82.3%的女性中，有88.6%发生早产，11.4%足月分娩。此外，UCN水平≥92 pg/mL的女性中，88.2%在7天内分娩，仅11.8%在7天后分娩。然而，UCN水平<92 pg/mL 的女性中，58.2%在7天内分娩，41.8%在7天后分娩。
结论
UCN临界值≥92 pg/mL可预测入院后7天内发生的早产。
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