脂联素基因多态性与心血管疾病的关系：荟萃分析。
Association between polymorphisms in the adiponectin gene and cardiovascular disease: a meta-analysis.
机构信息
State Key Laboratory of Cardiovascular Disease, Department of Evidence Based Medicine and Division of Population Genetics, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
出版信息
BMC Med Genet. 2012 May 28;13:40. doi: 10.1186/1471-2350-13-40.
BACKGROUND
Previous studies have examined the associations between polymorphisms of adiponectin gene (ADIPOQ) and cardiovascular disease (CVD), but those studies have been inconclusive. The aim of this study was to access the relationship between three single nucleotide polymorphisms (SNPs), +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729) in ADIPOQ and CVD.
METHODS
A comprehensive search was conducted to identify all studies on the association of ADIPOQ gene polymorphisms with CVD risk. The fixed and random effect pooled measures (i.e. odds ratio (OR) and 95% confidence interval (CI)) were calculated in the meta-analysis. Heterogeneity among studies was evaluated using Q test and the I2. Publication bias was estimated using modified Egger's linear regression test.
RESULTS
Thirty-seven studies concerning the associations between the three polymorphisms of ADIPOQ gene and CVD risk were enrolled in this meta-analysis, including 6,398 cases and 10,829 controls for rs2241766, 8,392 cases and 18,730 controls for rs1501299 and 7,835 cases and 14,023 controls for rs266729. The three SNPs were significantly associated with CVD, yielding pooled ORs of 1.22 (95%CI: 1.07, 1.39; P = 0.004), 0.90 (95%CI: 0.83, 0.97; P = 0.007) and 1.09(95%CI: 1.01, 1.17; P = 0.032) for rs2241766, rs1501299 and rs266729, respectively. Rs2241766 and rs1501299 were significantly associated with coronary heart disease (CHD), yielding pooled ORs of 1.29 (95%CI: 1.09, 1.52; P = 0.004) and 0.89 (95%CI: 0.81, 0.99; P = 0.025), respectively. The pooled OR for rs266729 and CHD was 1.09 (95%CI: 0.99, 1.19; P = 0.090). Significant between-study heterogeneity was found in our meta-analysis. Evidence of publication bias was observed in the meta-analysis.
CONCLUSIONS
The present meta-analysis showed that the associations between rs2241766, rs1501299 and rs266729 in the ADIPOQ and CVD were significant but weak. High quality studies are still needed to confirm the associations, especially for rs2241766.
背景
先前的研究已经探讨了脂联素基因（ADIPOQ）多态性与心血管疾病（CVD）之间的关联，但这些研究尚无定论。本研究旨在评估 ADIPOQ 基因中的三个单核苷酸多态性（SNP）+45T>G（rs2241766）、+276G>T（rs1501299）和-11377C>G（rs266729）与 CVD 之间的关系。
方法
进行了全面的检索，以确定所有关于 ADIPOQ 基因多态性与 CVD 风险关联的研究。使用固定和随机效应合并措施（即比值比（OR）和 95%置信区间（CI））进行荟萃分析。使用 Q 检验和 I2 评估研究之间的异质性。使用修正的 Egger 线性回归检验估计发表偏倚。
结果
本荟萃分析纳入了 37 项关于 ADIPOQ 基因三个多态性与 CVD 风险关联的研究，包括 rs2241766 与 6398 例病例和 10829 例对照，rs1501299 与 8392 例病例和 18730 例对照，rs266729 与 7835 例病例和 14023 例对照。三个 SNP 与 CVD 显著相关，产生的合并 OR 分别为 1.22（95%CI：1.07，1.39；P=0.004）、0.90（95%CI：0.83，0.97；P=0.007）和 1.09（95%CI：1.01，1.17；P=0.032）。rs2241766 和 rs1501299 与冠心病（CHD）显著相关，产生的合并 OR 分别为 1.29（95%CI：1.09，1.52；P=0.004）和 0.89（95%CI：0.81，0.99；P=0.025）。rs266729 与 CHD 的合并 OR 为 1.09（95%CI：0.99，1.19；P=0.090）。荟萃分析中存在显著的异质性。荟萃分析中观察到发表偏倚的证据。
结论
本荟萃分析表明，ADIPOQ 基因中的 rs2241766、rs1501299 和 rs266729 与 CVD 之间的关联虽然显著但较弱。仍需要高质量的研究来证实这些关联，尤其是对于 rs2241766。
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