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Selection of pulmonary resection procedures to reduce postoperative complications in 200 patients.200 例患者中减少术后并发症的肺切除术选择。
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2
Thoracic and cardiovascular surgery in Japan during 2008: annual report by The Japanese Association for Thoracic Surgery.2008年日本胸心血管外科：日本胸外科学会年度报告
Gen Thorac Cardiovasc Surg. 2010 Jul;58(7):356-83. doi: 10.1007/s11748-010-0604-0.
3
Neutrophil elastase inhibitor improves postoperative clinical courses after thoracic esophagectomy.中性粒细胞弹性蛋白酶抑制剂可改善胸段食管癌切除术后的临床病程。
Dis Esophagus. 2007;20(6):478-86. doi: 10.1111/j.1442-2050.2007.00699.x.
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Selection of pulmonary resection procedures to avoid postoperative complications.选择肺切除手术以避免术后并发症。
Surg Today. 2007;37(3):202-6. doi: 10.1007/s00595-006-3374-7. Epub 2007 Mar 9.
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Cutting edge: an endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4.前沿：通过Toll样受体4引发全身炎症反应综合征（SIRS）样反应的内源性途径。
J Immunol. 2004 Jan 1;172(1):20-4. doi: 10.4049/jimmunol.172.1.20.
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Administration of C1 inhibitor reduces neutrophil activation in patients with sepsis.给予C1抑制剂可降低脓毒症患者的中性粒细胞活化。
Clin Diagn Lab Immunol. 2003 Jul;10(4):529-35. doi: 10.1128/cdli.10.4.529-535.2003.
7
Neutrophil elastase up-regulates interleukin-8 via toll-like receptor 4.中性粒细胞弹性蛋白酶通过Toll样受体4上调白细胞介素-8。
FEBS Lett. 2003 Jun 5;544(1-3):129-32. doi: 10.1016/s0014-5793(03)00482-4.
8
Neutrophil elastase enhances macrophage production of chemokines in receptor-mediated reaction.中性粒细胞弹性蛋白酶在受体介导反应中增强巨噬细胞趋化因子的产生。
Res Commun Mol Pathol Pharmacol. 1999 Feb;103(2):139-47.
9
ONO-5046 is a potent inhibitor of neutrophil elastase in human pleural effusion after lobectomy.ONO - 5046是肺叶切除术后人胸腔积液中中性粒细胞弹性蛋白酶的强效抑制剂。
Eur J Pharmacol. 1998 Jul 24;353(2-3):273-9. doi: 10.1016/s0014-2999(98)00412-9.
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Pulmonary endothelial permeability changes after major lung resection.肺叶切除术后肺内皮通透性的变化
Ann Thorac Surg. 1996 May;61(5):1435-40. doi: 10.1016/0003-4975(96)00103-8.

肺切除术中肺静脉血中的中性粒细胞弹性蛋白酶活性

Neutrophil elastase activity in pulmonary venous blood during lung resection.

作者信息

Nagamatsu Yoshinori, Iwasaki Yasunori, Omura Harutaka, Hayashida Ryozo, Kashihara Masaki, Nishi Tatsuya, Yoshiyama Koichi, Shirouzu Kazuo

机构信息

Department of Surgery, National Hospital Organization Omuta National Hospital, Ohmuta Fukuoka, Japan.

出版信息

Interact Cardiovasc Thorac Surg. 2012 Sep;15(3):452-5. doi: 10.1093/icvts/ivs010. Epub 2012 May 28.

DOI:10.1093/icvts/ivs010
PMID:22641841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3422913/
Abstract

OBJECTIVES

Neutrophil elastase has been reported to play an important role in acute lung injury, which is a major cause of postoperative mortality after pulmonary resection. Neutrophil elastase released in the lungs reaches the peripheral circulation via the pulmonary veins. This study was performed to compare neutrophil elastase activity in pulmonary venous blood (collected during lobectomy) with that in the peripheral blood, and to determine the perioperative changes of neutrophil elastase activity.

METHODS

In 34 patients undergoing lobectomy with mediastinal lymph node dissection, the leucocyte count, neutrophil count, neutrophil elastase activity and levels of tumour necrosis factor-α, interleukin-6 and interleukin-8 were measured in the pulmonary venous blood and peripheral arterial blood before and after surgery. Then, these parameters were compared between before and after surgery with peripheral and pulmonary blood.

RESULTS

Neutrophil elastase activity was found to be significantly higher in pulmonary venous blood at the completion of surgery than at the start (during thoracotomy), while the neutrophil elastase activity of peripheral arterial blood showed no significant change between the start and completion of surgery.

CONCLUSIONS

In conclusion, measurement of neutrophil elastase activity in pulmonary venous blood revealed changes associated with lobectomy.

摘要

目的

据报道，中性粒细胞弹性蛋白酶在急性肺损伤中起重要作用，急性肺损伤是肺切除术后死亡的主要原因。肺中释放的中性粒细胞弹性蛋白酶通过肺静脉到达外周循环。本研究旨在比较肺静脉血（在肺叶切除术中采集）和外周血中的中性粒细胞弹性蛋白酶活性，并确定围手术期中性粒细胞弹性蛋白酶活性的变化。

方法

对34例行肺叶切除术并纵隔淋巴结清扫术的患者，在手术前后分别测定其肺静脉血和外周动脉血中的白细胞计数、中性粒细胞计数、中性粒细胞弹性蛋白酶活性以及肿瘤坏死因子-α、白细胞介素-6和白细胞介素-8水平。然后，将手术前后外周血和肺血的这些参数进行比较。

结果

发现手术结束时肺静脉血中的中性粒细胞弹性蛋白酶活性明显高于手术开始时（开胸期间），而外周动脉血中的中性粒细胞弹性蛋白酶活性在手术开始和结束之间无明显变化。

结论

总之，测定肺静脉血中的中性粒细胞弹性蛋白酶活性揭示了与肺叶切除术相关的变化。