Rutten V P, Misdorp W, Gauthier A, Estrada M, Mialot J P, Parodi A L, Rutteman G R, Weyer K
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
Vet Immunol Immunopathol. 1990 Nov;26(3):211-25. doi: 10.1016/0165-2427(90)90092-7.
Naturally occurring cancer in companion animals parallels cancer in man more closely than does experimentally induced cancer in inbred laboratory animals. In dogs and cats, as in man, a role for immune responses is indicated in the development of tumors. A survey is presented based on the literature and our own studies concerning the immunological and immunotherapeutic aspects of canine and feline mammary neoplasia. In dogs bearing mammary neoplasms, circulating immune complexes appear to play a negative role in the generation of effective antitumor immune responses. The functional role of peripheral blood lymphocytes and tumor-infiltrating lymphocytes in dogs and cats with mammary tumors is not yet fully established. No tumor antigen responsible for humoral or cellular responses has yet been identified. Extracorporeal perfusion of serum of dogs with mammary tumors and subcutaneous administration of mitomycin- and neuraminidase-treated autologous tumor cells are associated with improved prognosis. The opposite was true for i.v. treatment with BCG or Corynebacterium parvum vaccine in our study, in contrast to a previous report. A number of other treatment modalities in cats and dogs with mammary carcinomas failed to induce tumor regression. Canine and feline mammary carcinomas are good candidates for modern immunotherapeutic approaches.
伴侣动物的自然发生癌症比近交实验动物中的实验诱导癌症更接近人类癌症。在狗和猫中，如同在人类中一样，免疫反应在肿瘤发展中显示出作用。本文基于文献及我们自己关于犬猫乳腺肿瘤免疫和免疫治疗方面的研究进行综述。在患有乳腺肿瘤的犬中，循环免疫复合物似乎在产生有效的抗肿瘤免疫反应中起负面作用。外周血淋巴细胞和肿瘤浸润淋巴细胞在患有乳腺肿瘤的犬猫中的功能作用尚未完全明确。尚未鉴定出负责体液或细胞反应的肿瘤抗原。对患有乳腺肿瘤的犬血清进行体外灌注以及皮下注射丝裂霉素和神经氨酸酶处理的自体肿瘤细胞与预后改善相关。在我们的研究中，与先前的报告相反，静脉注射卡介苗或短小棒状杆菌疫苗的情况则相反。许多其他治疗方式对患有乳腺癌的猫和犬未能诱导肿瘤消退。犬猫乳腺癌是现代免疫治疗方法的良好候选对象。
