Wu Kainan, Chang Fen, Li Wenming, Su Tongdong, Lei Dapeng
Key Laboratory of Otolaryngology, NHFPC (Shandong University), Shandong, China.
Department of Otorhinolaryngology, Qilu Hospital, Shandong University, Shandong, China.
Front Oncol. 2022 Sep 27;12:1003808. doi: 10.3389/fonc.2022.1003808. eCollection 2022.
IGF2BPs belongs to a family of conserved RNA-bound oncoembryonic proteins that play a crucial part in various aspects of cell function, such as cell migration, morphology, metabolism, proliferation and differentiation. Recent studies have shown that IGF2BPs play a role as a member of m6A reader. m6A is the most abundant modification in RNA epigenetics, which is closely related to a family of RNA-binding proteins. These proteins are fell into three categories-writers, readers and erasers. In the present study, IGF2BPs play an important role in tumor metabolism, especially in head and neck squamous cell carcinoma (HNSCC) metabolism. In this paper, the basic structure of IGF2BPs, its role in the development of HNSCC, molecular mechanism, research progress and research prospect of IGF2BPs in HNSCC are reviewed, which will providing new ideas for further study of IGF2BPs.
胰岛素样生长因子2结合蛋白（IGF2BPs）属于一类保守的RNA结合胚胎癌蛋白家族，在细胞功能的各个方面发挥着关键作用，如细胞迁移、形态、代谢、增殖和分化。最近的研究表明，IGF2BPs作为m6A阅读蛋白家族的一员发挥作用。m6A是RNA表观遗传学中最丰富的修饰，它与一类RNA结合蛋白密切相关。这些蛋白分为三类——写入蛋白、阅读蛋白和擦除蛋白。在本研究中，IGF2BPs在肿瘤代谢中发挥重要作用，尤其是在头颈部鳞状细胞癌（HNSCC）代谢中。本文综述了IGF2BPs的基本结构、其在HNSCC发生发展中的作用、分子机制、研究进展以及在HNSCC中的研究前景，这将为进一步研究IGF2BPs提供新思路。
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