Cdt1 使动粒微管连接发生缠绕。
Cdt1 throws kinetochore-microtubule attachments for a loop.
出版信息
Nat Cell Biol. 2012 May 30;14(6):561-3. doi: 10.1038/ncb2513.
Abstract
The Ndc80 complex links spindle microtubules to the kinetochore to ensure the proper segregation of chromosomes during mitosis. Analysis of the replication licensing factor Cdt1 during mitosis now reveals a cooperative role with the Ndc80 complex in establishing stable microtubule attachments to the spindle.
摘要
Ndc80 复合物将纺锤体微管与动粒连接起来，以确保有丝分裂过程中染色体的正确分离。目前对有丝分裂过程中复制许可证因子 Cdt1 的分析揭示了它与 Ndc80 复合物在建立纺锤体微管与动粒稳定连接方面的合作作用。
相似文献
1
Cdt1 throws kinetochore-microtubule attachments for a loop.
Nat Cell Biol. 2012 May 30;14(6):561-3. doi: 10.1038/ncb2513.
2
The Ndc80-Cdt1-Ska1 complex is a central processive kinetochore-microtubule coupling unit.
J Cell Biol. 2023 Aug 7;222(8). doi: 10.1083/jcb.202208018. Epub 2023 Jun 2.
3
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Nat Cell Biol. 2012 May 13;14(6):593-603. doi: 10.1038/ncb2489.
4
The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore-microtubule attachment formation and Ska complex recruitment.
Mol Biol Cell. 2020 Jul 1;31(14):1453-1473. doi: 10.1091/mbc.E20-05-0286. Epub 2020 May 13.
5
Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism.
J Cell Biol. 2018 Oct 1;217(10):3446-3463. doi: 10.1083/jcb.201705127. Epub 2018 Aug 28.
6
Kinetochore-microtubule coupling mechanisms mediated by the Ska1 complex and Cdt1.
Essays Biochem. 2020 Sep 4;64(2):337-347. doi: 10.1042/EBC20190075.
7
Chmp4c is required for stable kinetochore-microtubule attachments.
Chromosoma. 2018 Dec;127(4):461-473. doi: 10.1007/s00412-018-0675-8. Epub 2018 Jul 2.
8
Astrin-SKAP complex reconstitution reveals its kinetochore interaction with microtubule-bound Ndc80.
Elife. 2017 Aug 25;6:e26866. doi: 10.7554/eLife.26866.
9
Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis.
J Biol Chem. 2018 Apr 20;293(16):5755-5765. doi: 10.1074/jbc.RA117.001699. Epub 2018 Feb 23.
10
How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.
Bioarchitecture. 2015;5(1-2):1-12. doi: 10.1080/19490992.2015.1090669. Epub 2015 Oct 2.
引用本文的文献
1
A new class of cytotoxic agents targets tubulin and disrupts microtubule dynamics.
Bioorg Chem. 2021 Nov;116:105297. doi: 10.1016/j.bioorg.2021.105297. Epub 2021 Aug 30.
2
Effect of NDC80 in human hepatocellular carcinoma.
World J Gastroenterol. 2017 May 28;23(20):3675-3683. doi: 10.3748/wjg.v23.i20.3675.
3
Coiled-coils: The long and short of it.
Bioessays. 2016 Sep;38(9):903-16. doi: 10.1002/bies.201600062. Epub 2016 Aug 5.
4
Synergistic Control of Kinetochore Protein Levels by Psh1 and Ubr2.
PLoS Genet. 2016 Feb 18;12(2):e1005855. doi: 10.1371/journal.pgen.1005855. eCollection 2016 Feb.
5
Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.
Chromosoma. 2015 Dec;124(4):463-80. doi: 10.1007/s00412-015-0515-z. Epub 2015 Apr 28.
6
The KMN protein network--chief conductors of the kinetochore orchestra.
J Cell Sci. 2012 Dec 15;125(Pt 24):5927-36. doi: 10.1242/jcs.093724. Epub 2013 Feb 15.
本文引用的文献
1
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Nat Cell Biol. 2012 May 13;14(6):593-603. doi: 10.1038/ncb2489.
2
Structural and functional organization of the Ska complex, a key component of the kinetochore-microtubule interface.
Mol Cell. 2012 May 11;46(3):274-86. doi: 10.1016/j.molcel.2012.03.005. Epub 2012 Apr 5.
3
The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.
Mol Biol Cell. 2011 Apr 15;22(8):1217-26. doi: 10.1091/mbc.E10-07-0626. Epub 2011 Feb 16.
4
Ndc80 internal loop interacts with Dis1/TOG to ensure proper kinetochore-spindle attachment in fission yeast.
Curr Biol. 2011 Feb 8;21(3):214-20. doi: 10.1016/j.cub.2010.12.048. Epub 2011 Jan 20.
5
The Ndc80 loop region facilitates formation of kinetochore attachment to the dynamic microtubule plus end.
Curr Biol. 2011 Feb 8;21(3):207-13. doi: 10.1016/j.cub.2010.12.050. Epub 2011 Jan 20.
6
The Ndc80 kinetochore complex forms oligomeric arrays along microtubules.
Nature. 2010 Oct 14;467(7317):805-10. doi: 10.1038/nature09423.
7
Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B.
J Cell Biol. 2010 May 17;189(4):713-23. doi: 10.1083/jcb.200910142.
8
Protein architecture of the human kinetochore microtubule attachment site.
Cell. 2009 May 15;137(4):672-84. doi: 10.1016/j.cell.2009.03.035.
9
In vivo protein architecture of the eukaryotic kinetochore with nanometer scale accuracy.
Curr Biol. 2009 Apr 28;19(8):694-9. doi: 10.1016/j.cub.2009.02.056. Epub 2009 Apr 2.
10
Microtubule polymerases and depolymerases.
Curr Opin Cell Biol. 2007 Feb;19(1):31-5. doi: 10.1016/j.ceb.2006.12.009. Epub 2006 Dec 20.
Zotero 插件