Neurological Department, C. Massaja Hospital, Via Conte Verde 200, 10141 Asti, Italy.
Neurol Sci. 2012 May;33 Suppl 1:S9-11. doi: 10.1007/s10072-012-1034-9.
An impaired processing of sensory afferents in the brainstem plays a key role in the development of migraine attack and for many of its clinical aspects. The repetition or prolonged of painful stimuli over time would be able to produce a prolonged and reversible increase of excitability and synaptic efficacy in the nociceptive pathways of the central nervous system. This phenomenon, known as sensitization, involves specifically the caudal trigeminal nucleus. Being an aspect of untreated migraine, allodynia is more common in patients with chronic migraine and migraine with aura, often associated with motor and sensory symptoms sometimes present during the attacks. The presence of allodynia in the course of migraine attack greatly increases the disability of the patient and its recognition, as well as from a therapeutic point of view, it is essential in the management of migraine patients.
大脑脑干中感觉传入的处理受损在偏头痛发作的发展和许多临床方面中起着关键作用。随着时间的推移，重复或延长疼痛刺激将能够在中枢神经系统的伤害性通路中产生持久和可逆的兴奋性和突触效能增加。这种现象称为敏化，具体涉及尾状三叉神经核。作为未经治疗的偏头痛的一个方面，感觉过敏在慢性偏头痛和有先兆偏头痛患者中更为常见，常与运动和感觉症状相关，有时在发作期间出现。偏头痛发作过程中出现感觉过敏会极大地增加患者的残疾程度及其识别程度，并且从治疗角度来看，它在偏头痛患者的管理中至关重要。
