用于引产的不同药物的体外子宫肌收缩性特征。
In vitro myometrial contractility profiles of different pharmacological agents used for induction of labor.
机构信息
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555-0144, USA.
出版信息
Am J Perinatol. 2012 Oct;29(9):699-704. doi: 10.1055/s-0032-1314891. Epub 2012 May 29.
OBJECTIVE
To investigate the effects of different pharmacological induction agents on myometrial contractility.
STUDY DESIGN
Myometrial biopsies were obtained from 13 term nonlaboring women undergoing scheduled cesarean delivery. Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 mol/L to 10-5 mol/L) of prostaglandin E1 (PGE1), E2 (PGE2), and oxytocin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using one-way analysis of variance on ranks with Dunn post hoc test.
RESULTS
Oxytocin-induced myometrial contractility was superior to PGE1, PGE2, and time controls (CTR) at all the concentrations tested. When only prostaglandins were compared with CTR, PGE1 10-5 mol/L increased myometrial contractility, and PGE2 had no effects.
CONCLUSION
Oxytocin and prostaglandins have different effects on myometrial contractility accounting for different mechanisms of action and side effects. The increased uterine contractility observed with PGE1 as compared with PGE2 can contribute to explain the higher success of vaginal delivery.
目的
研究不同药理诱导剂对子宫肌收缩性的影响。
研究设计
从 13 名接受择期剖宫产的足月未产妇中获取子宫活检组织。组织条被悬挂在器官室中进行等长张力记录。确定前列腺素 E1（PGE1）、E2（PGE2）和催产素的累积剂量（10-10 mol/L 至 10-5 mol/L）对自发性子宫收缩性的影响。使用秩和单向方差分析和 Dunn 事后检验比较收缩曲线下面积。
结果
在所有测试浓度下，催产素诱导的子宫收缩性均优于 PGE1、PGE2 和时间对照（CTR）。当仅将前列腺素与 CTR 进行比较时，PGE1 10-5 mol/L 增加了子宫收缩性，而 PGE2 没有影响。
结论
催产素和前列腺素对子宫收缩性的影响不同，这归因于不同的作用机制和副作用。与 PGE2 相比，PGE1 观察到的子宫收缩性增加可以解释阴道分娩成功率更高的原因。
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