前列腺素 E1 和前列腺素 E2 对体外子宫平滑肌收缩性和子宫结构的影响。
The effects of prostaglandin E1 and prostaglandin E2 on in vitro myometrial contractility and uterine structure.
机构信息
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555-0144, USA.
出版信息
Am J Perinatol. 2012 Sep;29(8):615-22. doi: 10.1055/s-0032-1311986. Epub 2012 May 25.
OBJECTIVE
To estimate the effects of prostaglandin E1 (PGE1) and E2 (PGE2) on myometrial contractility and structure in vitro.
STUDY DESIGN
Myometrial strips from 18 women were incubated with PGE1 (10-5 mol/L), PGE2 (10-5 mol/L), or solvent (CTR) for up to 360 minutes in organ chambers for isometric tension recording. The area under the contraction curve, total collagen content, and percentage of the area covered by connective tissue were calculated at various time periods.
RESULTS
PGE1 significantly increased in vitro myometrial contractility up to 90 minutes when compared with PGE2 and CTR (p < 0.01) and up to 180 minutes as compared with PGE2 (p < 0.05). After 360 minutes, CTR and PGE1 samples had lower total collagen content and area covered by connective tissue than PGE2 (p < 0.01).
CONCLUSION
The effects of prostaglandins on the uterus cannot be solely explained by contractility. Treatment with PGE1 significantly increased myometrial contractions and decreased both total collagen content and the area covered by connective tissue. Such findings may explain the higher rates of vaginal delivery, tachysystole, and uterine rupture associated with PGE1 use.
目的
评估前列腺素 E1（PGE1）和 E2（PGE2）对体外子宫收缩力和结构的影响。
研究设计
在器官室中，将来自 18 名女性的子宫肌条与 PGE1（10-5mol/L）、PGE2（10-5mol/L）或溶剂（CTR）孵育长达 360 分钟，用于等长张力记录。在不同时间点计算收缩曲线下面积、总胶原含量和结缔组织覆盖面积的百分比。
结果
与 PGE2 和 CTR（p<0.01）相比，PGE1 在体外可显著增加子宫收缩力，持续至 90 分钟，与 PGE2 相比，持续至 180 分钟（p<0.05）。360 分钟后，CTR 和 PGE1 样本的总胶原含量和结缔组织覆盖面积均低于 PGE2（p<0.01）。
结论
不能仅通过收缩力来解释前列腺素对子宫的影响。与 PGE2 相比，PGE1 治疗可显著增加子宫收缩力，同时降低总胶原含量和结缔组织覆盖面积。这些发现可能解释了与 PGE1 使用相关的阴道分娩率、宫缩过速和子宫破裂的发生率较高的原因。
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