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聚合物囊泡作为人工细胞样结构的蛋白质表达、聚集和触发释放。

Protein expression, aggregation, and triggered release from polymersomes as artificial cell-like structures.

机构信息

The Division of Biomedical Engineering, School of Engineering, The University of Glasgow, Glasgow, G12 8LT, UK.

出版信息

Angew Chem Int Ed Engl. 2012 Jun 25;51(26):6416-20. doi: 10.1002/anie.201201443. Epub 2012 May 29.

DOI:10.1002/anie.201201443
PMID:22644870
Abstract

Bringing droplets to life: A cytoskeletal protein (red dots, see scheme) is expressed in artificial cells composed of biocompatible polymersomes, which encapsulate expression machinery and amino acid building blocks. Release of the expressed proteins can be triggered by a negative osmotic shock.

摘要

使液滴“活”起来：一种细胞骨架蛋白（红色小点，见方案）在由生物相容性聚合物囊泡组成的人工细胞中表达，这些囊泡包裹着表达机制和氨基酸构建块。表达蛋白的释放可以通过负渗透压冲击来触发。

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