Niczyporuk Marek, Hermanowicz Adam, Matuszczak Ewa, Dziadziuszko Rafał, Knaś Małgorzata, Zalewska Anna, Chyczewski Lech
Laboratory of Esthetic Medicine, Medical University of Bialystok, Bialystok, Poland.
Exp Lung Res. 2012 Aug;38(6):281-5. doi: 10.3109/01902148.2012.686559. Epub 2012 May 30.
Although a direct association between mast cells and cancer tumors is generally accepted, the exact nature of this relationship appears contradictory. The aim of this study was to clarify the effect of mast cells on tumor angiogenesis and outcome in Non-small cell lung cancer (NSCLC) patients. The tissue specimens evaluated were from patients with NSCLC who had undergone resection with curative intent at the Medical University of Bialystok Hospital. Of the 90 patients studied, 67 were men. Average age at surgery was 59.68 years. Study population included 29 cases of adenocarcinoma, 44 cases of squamous cell carcinoma, and 17 cases of large cell carcinoma. The authors counted mast cells and microvessels in tumor sections. Mast cells were observed in small groups around vessels and in the cancer parenchyma. At a magnification of 200×, the number of mast cells was 28.90 ± 16.6. Intramural microvessels in endothelial cells were found in small groups, mostly at the margin. At a magnification of 200×, the number of microvessels was 221.69 ± 120.36. Spearman correlation was observed in patients with adenocarcinoma, and also in patients with stage II disease. This study did not show correlation between mast cells count and survival rate, and correlation between microvessel count and survival rate. In this study, mast cells infiltration of the tumor islets was not associated with patients' survival. The authors did not find correlation between mast cells count and angiogenesis, except only in patients with adenocarcinoma, and in patients with stage II disease.
尽管肥大细胞与癌症肿瘤之间的直接关联已被普遍接受，但这种关系的确切性质似乎相互矛盾。本研究的目的是阐明肥大细胞对非小细胞肺癌（NSCLC）患者肿瘤血管生成及预后的影响。所评估的组织标本来自在比亚韦斯托克医科大学医院接受根治性切除的NSCLC患者。在研究的90例患者中，67例为男性。手术时的平均年龄为59.68岁。研究人群包括29例腺癌、44例鳞状细胞癌和17例大细胞癌。作者对肿瘤切片中的肥大细胞和微血管进行了计数。肥大细胞在血管周围小群出现，并存在于癌实质中。在200倍放大倍数下，肥大细胞数量为28.90±16.6。内皮细胞内的壁内微血管小群出现，大多位于边缘。在200倍放大倍数下，微血管数量为221.69±120.36。在腺癌患者以及II期疾病患者中观察到斯皮尔曼相关性。本研究未显示肥大细胞计数与生存率之间的相关性，以及微血管计数与生存率之间的相关性。在本研究中，肿瘤小岛的肥大细胞浸润与患者生存率无关。作者未发现肥大细胞计数与血管生成之间的相关性，仅在腺癌患者以及II期疾病患者中除外。
