生殖器和非生殖器部位硬化性苔藓的临床、皮肤镜和组织病理学特征。
Clinical, dermoscopic and histopathologic features of genital and extragenital lichen sclerosus.
机构信息
Dermatology Unit. Hospital de Clínicas 'Dr. Manuel Quintela'. Montevideo, UruguayClinic of Dermatovenerology, Clinical Center of Nis, Medical Faculty University of Nis, Nis, SerbiaState Clinic of Dermatology, Hospital of Skin and Venereal Diseases, Thessaloniki, GreeceDepartment of Dermatology, University of Modena and Reggio Emilia, Modena, Italy and Dermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS; Reggio Emilia, ItalyDermatology and Skin Cancer Unit, Arcispedale Santa Maria Nuova, IRCCS, Reggio Emilia, Italy.
出版信息
J Eur Acad Dermatol Venereol. 2013 Nov;27(11):1433-9. doi: 10.1111/j.1468-3083.2012.04595.x. Epub 2012 May 31.
BACKGROUND
Little is currently known about the dermoscopic patterns of genital and extragenital lichen sclerosus (LS). In order to evaluate and compare the dermoscopic and histopathologic patterns of genital and extragenital lichen sclerosus, a retrospective analysis of clinical, dermoscopic and histopathologic features of genital and extragenital LS, collected between March 2010 and December 2011 at four dermatology clinics in Greece, Italy, Serbia and Uruguay was performed.
OBSERVATIONS
A total of 29 lesions from 14 (mean age 62.8 years) and 12 (mean age 53.5 years) patients with genital and extragenital LS, respectively were analyzed. Mean duration of disease was 3.5 years for genital and 1.8 years for extragenital LS. White-yellowish structureless areas were seen in all cases of genital and extragenital LS; however linear vessels occurred at higher frequency in genital than in extragenital lesions (85.7% vs. 33.3%, respectively). Extragenital LS revealed two different time-related patterns: keratotic plugs were more prevalent in lesions with short duration (<2 years), whereas longer persisting lesions appeared atrophic and revealed fine chrysalis structures.
CONCLUSIONS
Our morphologic study provides novel insights into the morphologic diversity of LS at different body sites and different stages of progression.
背景
目前对于生殖器和外阴硬化性苔藓（LS）的皮肤镜模式知之甚少。为了评估和比较生殖器和外阴 LS 的皮肤镜和组织病理学模式，对 2010 年 3 月至 2011 年 12 月在希腊、意大利、塞尔维亚和乌拉圭的四家皮肤科诊所收集的生殖器和外阴 LS 的临床、皮肤镜和组织病理学特征进行了回顾性分析。
观察结果
共分析了 14 例生殖器 LS（平均年龄 62.8 岁）和 12 例外阴 LS（平均年龄 53.5 岁）患者的 29 个病变。生殖器 LS 的平均病程为 3.5 年，外阴 LS 为 1.8 年。所有生殖器和外阴 LS 病例均可见白色-黄白色无结构区域；然而，生殖器病变中线性血管的发生率高于外阴病变（分别为 85.7%和 33.3%）。外阴 LS 呈现出两种不同的与时间相关的模式：角化栓在病程较短（<2 年）的病变中更为常见，而持续时间较长的病变则呈现萎缩并显示出细小的蝶形结构。
结论
我们的形态学研究为不同部位和不同进展阶段 LS 的形态多样性提供了新的见解。
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