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本文引用的文献

1
Reciprocal seasonal variation in vitamin D status and tuberculosis notifications in Cape Town, South Africa.南非开普敦维生素 D 状况和结核病报告的季节性相互变化。
Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):19013-7. doi: 10.1073/pnas.1111825108. Epub 2011 Oct 24.
2
Seasonality of tuberculosis.结核病的季节性
J Glob Infect Dis. 2011 Jan;3(1):46-55. doi: 10.4103/0974-777X.77296.
3
Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals.维生素 D 状态季节性对健康个体细胞因子反应的调节。
Clin Exp Immunol. 2011 Apr;164(1):72-9. doi: 10.1111/j.1365-2249.2010.04315.x. Epub 2011 Feb 16.
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Vitamin d deficiency and tuberculosis progression.维生素 D 缺乏与结核病进展。
Emerg Infect Dis. 2010 May;16(5):853-5. doi: 10.3201/eid1605.091693.
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Twenty years of pediatric tuberculous meningitis: a retrospective cohort study in the western cape of South Africa.二十年儿童结核性脑膜炎：南非西开普省的一项回顾性队列研究
Pediatrics. 2009;123(1):e1-8. doi: 10.1542/peds.2008-1353.
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Relationship between vitamin D, calcium and parathyroid hormone in Cape Town.开普敦维生素D、钙与甲状旁腺激素之间的关系。
J Clin Pathol. 2009 Jun;62(6):567-9. doi: 10.1136/jcp.2008.062877. Epub 2009 Feb 12.
7
Does vitamin D make the world go 'round'?维生素D能让世界运转吗？
Breastfeed Med. 2008 Dec;3(4):239-50. doi: 10.1089/bfm.2008.9984.
8
Human macrophage host defense against Mycobacterium tuberculosis.人类巨噬细胞对结核分枝杆菌的宿主防御。
Curr Opin Immunol. 2008 Aug;20(4):371-6. doi: 10.1016/j.coi.2008.05.014. Epub 2008 Jul 21.
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The time-table of tuberculosis.结核病的时间表。
Tubercle. 1948 Nov;29(11):245-51. doi: 10.1016/s0041-3879(48)80033-4.
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Ultraviolet-B radiation increases serum 25-hydroxyvitamin D levels: the effect of UVB dose and skin color.紫外线B辐射可提高血清25-羟基维生素D水平：紫外线B剂量及肤色的影响
J Am Acad Dermatol. 2007 Oct;57(4):588-93. doi: 10.1016/j.jaad.2007.03.004. Epub 2007 Jul 16.

结核性脑膜炎发病率的季节性变化与日照时间有关。

Seasonal variation in the incidence rate of tuberculous meningitis is associated with sunshine hours.

机构信息

Department of Paediatric Infectious Diseases - Immunology and Rheumatology, VU University Medical Center, Amsterdam, The Netherlands.

Department of Paediatrics and Child Health, Tygerberg Hospital, University of Stellenbosch, Cape Town, South Africa.

出版信息

Epidemiol Infect. 2013 Mar;141(3):459-62. doi: 10.1017/S0950268812001045. Epub 2012 May 31.

DOI:10.1017/S0950268812001045
PMID:22647556
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9151823/
Abstract

Tuberculous meningitis (TBM) is a severe complication of tuberculosis and occurs mainly during early childhood. The incidence rate of TBM varies with season, and serum vitamin D levels, which are dependent on sunlight, might play a role. We studied the association between TBM incidence rate and hours of sunshine in Cape Town, South Africa and found a significant association between the incidence rate of TBM and hours of sunshine 3 months earlier (incidence rate ratio per 100 sunshine hours 0·69, 95% confidence interval 0·54-0·88, P = 0·002). The association supports the hypothesis that vitamin D might play a role in the pathophysiology of TBM. Further prospective studies in which vitamin D status is measured are necessary to determine causality.

摘要

结核性脑膜炎（TBM）是结核病的严重并发症，主要发生在儿童早期。TBM 的发病率随季节而变化，而血清维生素 D 水平（依赖于阳光）可能发挥作用。我们研究了南非开普敦 TBM 发病率与日照时间之间的关系，发现 TBM 发病率与 3 个月前的日照时间之间存在显著关联（每 100 小时日照时间的发病率比 0·69，95%置信区间 0·54-0·88，P=0·002）。这种关联支持了维生素 D 可能在 TBM 的病理生理学中发挥作用的假设。需要进一步进行前瞻性研究来测量维生素 D 状态，以确定因果关系。