1st Orthopaedic Department, University of Athens, School of Medicine, Attikon University Hospital, Athens, Greece.
Med Sci Monit. 2012 Jun;18(6):RA89-96. doi: 10.12659/msm.882893.
Bacteria have been found to grow predominantly in biofilms. The initial stage includes the attachment of bacteria to the substratum. Bacterial growth and division then leads to the colonization of the surrounding area and the formation of the biofilm. The environment in a biofilm is not homogeneous; the bacteria in a multispecies biofilm are not randomly distributed, but rather are organized to best meet their needs. Although there is an initial understanding on the mechanisms of biofilm-associated antimicrobial resistance, this topic is still under investigation. A variety of approaches are being explored to overcome biofilm-associated antimicrobial resistance. A greater understanding of biofilm processes should lead to novel, effective control strategies for biofilm control and a resulting improvement in patient management.
已经发现细菌主要在生物膜中生长。初始阶段包括细菌附着在基质上。然后，细菌的生长和分裂导致周围区域的定植和生物膜的形成。生物膜中的环境不是均匀的；多菌种生物膜中的细菌不是随机分布的，而是为了满足其需要而进行组织的。尽管对生物膜相关抗菌耐药性的机制已经有了初步的了解，但这一主题仍在研究中。正在探索各种方法来克服生物膜相关的抗菌耐药性。对生物膜过程的进一步了解应该会为生物膜控制带来新的、有效的控制策略，并最终改善患者管理。
