Saha Sukanta, Scott James, Varghese Daniel, McGrath John
Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Queensland, Australia.
BMJ Open. 2012 May 30;2(3). doi: 10.1136/bmjopen-2012-001001. Print 2012.
There is growing evidence that delusional-like experiences (DLE) are associated with common mental disorders. In particular, a National Mental Health Survey conducted in Australia during 2007 reported an association between DLE and both anxiety disorder and major depressive disorder (MDD). However, the previous study did not examine this association with respect to subtypes of anxiety disorder nor with severity of MDD. The aim of this study was to examine the associations between DLE and both anxiety disorder and MDD in more detail based on an independent population sample.
Cross-sectional study.
Subjects were drawn from the Australian Survey of Mental Health and Wellbeing 1997 using a stratified multistage area sampling of persons living in private dwellings in all States and Territories of Australia.
Approximately 13 600 private dwellings were initially selected with one person aged 18 years or older from each dwelling invited to participate. In total, 10 641 individuals participated in the survey.
The Composite International Diagnostic Interview was used to identify individuals with DLE and Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition (DSM IV) lifetime diagnoses of anxiety disorders and MDD. The influence of various anxiety disorders and MDD on DLE was assessed with logistic regression.
Having a lifetime diagnosis of either any anxiety disorder or MDD was significantly associated with the endorsement of DLE. The association was found for each of the main anxiety disorders when examined separately. There was a dose-response relationship between increasing severity of MDD and higher odds of DLE endorsement.
DLE are associated with a wide range of anxiety disorders and are more prevalent in those with MDD. Understanding the relationship between DLE, anxiety disorders and depression may provide insights into shared pathways that underpin both psychotic disorders and common mental disorders.
越来越多的证据表明，类妄想体验（DLE）与常见精神障碍有关。特别是，2007年在澳大利亚进行的一项全国心理健康调查报道了DLE与焦虑症和重度抑郁症（MDD）之间的关联。然而，先前的研究并未就焦虑症的亚型或MDD的严重程度来考察这种关联。本研究的目的是基于一个独立的人群样本，更详细地考察DLE与焦虑症和MDD之间的关联。
横断面研究。
研究对象来自1997年澳大利亚心理健康与幸福调查，采用分层多阶段区域抽样法，选取澳大利亚所有州和领地居住在私人住宅中的人员。
最初选取了约13600处私人住宅，邀请每处住宅中一名18岁及以上的人员参与。共有10641人参与了调查。
采用复合国际诊断访谈来识别有DLE的个体以及符合《精神疾病诊断与统计手册》第四版（DSM-IV）终生诊断标准的焦虑症和MDD患者。采用逻辑回归评估各种焦虑症和MDD对DLE的影响。
终生诊断为任何一种焦虑症或MDD均与认可DLE显著相关。单独检查时，每种主要焦虑症均存在这种关联。MDD严重程度增加与认可DLE的较高几率之间存在剂量反应关系。
DLE与多种焦虑症有关，在MDD患者中更为普遍。了解DLE、焦虑症和抑郁症之间的关系可能有助于深入了解精神病性障碍和常见精神障碍共同的潜在途径。
