Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, RAS.
Acta Naturae. 2009 Jul;1(2):26-32.
The structure of the influenza virus neuraminidases, the spatial organization of their active site, the mechanism of carbohydrate chains desialylation by neuraminidase, and its role in the influenza virus function at different stages of the viral infectious cycle are considered in this review. Data on the neuraminidase substrate specificity and different approaches in studying the activity of this enzyme are summarized. In addition, data on neuraminidase inhibitors (as antivirals) are provided, along with considerations on the mechanisms of resistance of modern influenza viruses to those antivirals.
本文综述了流感病毒神经氨酸酶的结构、活性部位的空间组织、神经氨酸酶催化碳水化合物去唾液酸化的机制，以及其在流感病毒在病毒感染周期的不同阶段的功能中的作用。本文总结了神经氨酸酶底物特异性和研究该酶活性的不同方法的数据。此外，还提供了关于神经氨酸酶抑制剂（作为抗病毒药物）的数据，并考虑了现代流感病毒对这些抗病毒药物产生耐药性的机制。
