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以银屑病为模型研究免疫介导的炎症性疾病发病机制中的分子机制。

Study of Molecular Mechanisms Involved in the Pathogenesis of Immune-Mediated Inflammatory Diseases, using Psoriasis As a Model.

机构信息

Vavilov Institute of General Genetics, Russian Academy of Sciences;

出版信息

Acta Naturae. 2009 Oct;1(3):125-35.

PMID:22649625
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3347524/
Abstract

Psoriasis was used as a model to analyze the pathogenetic pathways of immune-mediated inflammatory diseases, and the results of bioinformatic, molecular-genetic and proteomic studies are provided. Cell mechanisms, common for the pathogenesis of psoriasis, as well as Crohn's disease, are identified. New approaches for immune-mediated diseases are discussed.

摘要

银屑病被用作分析免疫介导的炎症性疾病发病机制途径的模型，并提供了生物信息学、分子遗传学和蛋白质组学研究的结果。确定了银屑病发病机制以及克罗恩病共有的细胞机制。讨论了针对免疫介导性疾病的新方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/737fd8141ac4/AN20758251-03-125-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/e78d9967c3cf/AN20758251-03-125-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/586dc074625f/AN20758251-03-125-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/2f23e9b77e8e/AN20758251-03-125-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/cda849db6ef7/AN20758251-03-125-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/5326b841a505/AN20758251-03-125-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/fa1811a8ee54/AN20758251-03-125-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/737fd8141ac4/AN20758251-03-125-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/e78d9967c3cf/AN20758251-03-125-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4867/3347524/737fd8141ac4/AN20758251-03-125-g008.jpg

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本文引用的文献

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Chemokine receptors in T-cell-mediated diseases of the skin.
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[The comparative analysis of psoriasis and Crohn disease molecular-genetical processes under pathological conditions].
Mol Biol (Mosk). 2009 Jan-Feb;43(1):175-9.
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Type I interferon: potential therapeutic target for psoriasis?I型干扰素：银屑病的潜在治疗靶点？
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The Pathophysiological Mechanisms and the Quest for Biomarkers in Psoriasis, a Stress-Related Skin Disease.银屑病的病理生理机制与生物标志物探寻：一种与压力相关的皮肤疾病。
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Effect of Adalimumab on Gene Expression Profiles of Psoriatic Skin and Blood.阿达木单抗对银屑病皮肤和血液基因表达谱的影响。
J Drugs Dermatol. 2016 Aug 1;15(8):988-94.
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Pharmacological control of receptor of advanced glycation end-products and its biological effects in psoriasis.晚期糖基化终产物受体的药理学调控及其在银屑病中的生物学效应
Int J Biomed Sci. 2013 Sep;9(3):112-22.
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Fine mapping of the psoriasis susceptibility locus PSORS1 supports HLA-C as the susceptibility gene in the Han Chinese population.银屑病易感基因座PSORS1的精细定位支持HLA - C作为汉族人群中的易感基因。
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