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生物糖和天然糖苷作为生物有机化学中一个有前景的研究课题。

Bioglycans and natural glycosides as a promising research topic in bioorganic chemistriy.

机构信息

Institute of Physiology, Komi Science Center, The Urals Branch, Russian Academy of Sciences.

出版信息

Acta Naturae. 2010 Jul;2(2):28-36.

PMID:22649639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3347557/
Abstract

This review defines bioorganic chemistry as one of the most important constituents of physico-chemical biology, which is a fundamental life science. The problems and goals of bioorganic chemistry are examined through a comparatively small number of examples. Bioorganic chemistry is supposed to be a logical continuation of the chemistry of the natural substances that arose many years ago. Bioorganic chemistry has contributed some achievements in solving the problems of the chemical structure, biological function, and physiological activity of biopolymers and low-molecular-weight bioregulators, as well as in the elucidation of the molecular mechanisms of different life processes. The most striking achievements in bioorganic chemistry are discussed in this paper. However, this review discusses not only the general achievements in this field of science, but also research data obtained by scientists from the Pacific Institute of Bioorganic Chemistry, Far East Branch, Russian Academy of Sciences (Vladivostok, Russia), and the Institute of Physiology, Komi Science Centre, The Urals Branch, Russian Academy of Sciences (Syktyvkar, Russia). Particular attention is focused on comprehensive research into polysaccharides and biopolymers (bioglycans) and some natural glycosides that the author of this review has studied for a long time. The author has worked in these institutes for a long time and was honored by being chosen to head one of the scientific schools in the field of bioorganic chemistry and molecular immunology.

摘要

本文将生物有机化学定义为物理化学生物学的重要组成部分之一，而物理化学生物学是生命科学的基础。本文通过为数不多的实例来考察生物有机化学的问题和目标。生物有机化学被认为是多年前出现的天然物质化学的逻辑延续。生物有机化学在解决生物聚合物和低分子量生物调节剂的化学结构、生物功能和生理活性以及不同生命过程的分子机制阐明方面的问题上取得了一些成果。本文讨论了生物有机化学中最引人注目的成就。然而，本文不仅讨论了该科学领域的一般成就，还讨论了俄罗斯科学院远东分院太平洋生物有机化学研究所（俄罗斯符拉迪沃斯托克）和俄罗斯科学院科米科学中心生理研究所（俄罗斯斯维尔德洛夫斯克）的科学家们获得的研究数据。本文特别关注多糖和生物聚合物（生物糖胺聚糖）以及一些天然糖苷的综合研究，而作者本人长期以来一直在研究这些物质。作者长期在这些研究所工作，并荣幸地被选为生物有机化学和分子免疫学领域的一个科学学派的负责人。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f1/3347557/c9a9356bbe56/AN20758251-05-028-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f1/3347557/f817e2c7032f/AN20758251-05-028-g006.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f1/3347557/bd4bddb7b9a1/AN20758251-05-028-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f1/3347557/3a23df35e335/AN20758251-05-028-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/83f1/3347557/8d45e93c2cbc/AN20758251-05-028-g010.jpg
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