Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, Hubei, People's Republic of China.
Fitoterapia. 2012 Dec;83(8):1451-5. doi: 10.1016/j.fitote.2012.08.009. Epub 2012 Aug 25.
Three new enmein-type diterpenoids, jianshirubesins A-C (1-3), together with ten known compounds, were isolated from the aerial parts of Isodon rubescens. Their structures were established by using spectroscopic methods, and the absolute configuration of compound 1 was confirmed by a single-crystal X-ray diffraction analysis. All compounds except 3 were evaluated for their in vitro cytotoxicity by MTT assay, and compounds 5 and 10 exhibited significant inhibitory ability on selected cell lines.
从糙苏中分离得到三种新的冬凌草甲素型二萜化合物 Jianshirubesins A-C（1-3），以及 10 种已知化合物。通过光谱方法确定了它们的结构，通过单晶 X 射线衍射分析确定了化合物 1 的绝对构型。除 3 外，所有化合物均通过 MTT 法评估其体外细胞毒性，化合物 5 和 10 对选定的细胞系表现出显著的抑制能力。
