Regenerative Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon 305-806, Republic of Korea.
Curr Opin Neurobiol. 2012 Oct;22(5):778-84. doi: 10.1016/j.conb.2012.05.001. Epub 2012 May 30.
Recently we have witnessed an array of studies on direct reprogramming that describe induced inter conversion of mature cell types from higher organisms including human. While these studies reveal an unexpected level of plasticity of differentiated somatic cells, they also provide unprecedented opportunities to develop regenerative therapies for many debilitating disorders and model these 'diseases-in-a-dish' for studying their pathophysiology. Here we review the current state of the art in direct lineage reprogramming to neural cells, and discuss the challenges that need to be addressed toward achieving the full potential of this exciting new technology.
最近，我们见证了大量关于直接重编程的研究，这些研究描述了诱导高等生物（包括人类）成熟细胞类型的诱导相互转化。虽然这些研究揭示了分化体细胞具有出人意料的可塑性，但它们也为许多使人衰弱的疾病提供了前所未有的再生治疗机会，并为研究这些疾病的病理生理学提供了“在培养皿中模拟疾病”的模型。在这里，我们回顾了直接谱系重编程为神经细胞的最新技术进展，并讨论了实现这一令人兴奋的新技术的全部潜力所需要解决的挑战。
