澳南多龙，一种新的氨基嘧啶取代吲哚啉生物碱，来自一种南极被囊动物。

Australindolones, New Aminopyrimidine Substituted Indolone Alkaloids from an Antarctic Tunicate sp.

机构信息

Department of Chemistry, University of South Florida, 4202 E. Fowler Ave., CHE205, Tampa, FL 33620, USA.

Department of Preclinical Sciences and Pathology, Norwegian University of Life Sciences (NMBU), 1430 Ås, Norway.

出版信息

Mar Drugs. 2022 Mar 8;20(3):196. doi: 10.3390/md20030196.

DOI:10.3390/md20030196

PMID:35323495

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8949045/

Abstract

Five new alkaloids have been isolated from the lipophilic extract of the Antarctic tunicate sp. Deep-sea specimens of sp. were collected during a 2011 cruise of the R/V to the southern Scotia Arc, Antarctica. Crude extracts from the invertebrates obtained during the cruise were screened in a zebrafish-based phenotypic assay. The sp. extract induced embryonic dysmorphology characterized by axis truncation, leading to the isolation of aminopyrimidine substituted indolone (-) and indole (-) alkaloids. While the primary bioactivity tracked with previously reported meridianins A-G (-), further investigation resulted in the isolation and characterization of australindolones A-D (-) and the previously unreported meridianin H ().

摘要

从南极被囊动物 sp. 的脂溶性提取物中分离得到了 5 种新的生物碱。2011 年，在南极斯科舍海的 R/V 号考察船上采集了 sp. 的深海标本。在基于斑马鱼的表型测定中，对考察期间获得的无脊椎动物的粗提取物进行了筛选。sp. 提取物诱导胚胎畸形，表现为轴截断，导致氨基嘧啶取代的吲哚酮（-）和吲哚（-）生物碱的分离。虽然主要的生物活性与先前报道的 meridianins A-G（-）相吻合，但进一步的研究导致了 australindolones A-D（-）和以前未报道的 meridianin H（）的分离和表征。