Department of Surgery, Hushan Hospital, Fudan University, Shanghai, China.
Front Biosci (Landmark Ed). 2012 Jun 1;17(6):2350-5. doi: 10.2741/4056.
Breast cancer is the second leading cause of death due to cancer in women. Accumulating evidence shows a correlation between overexpression of miR-155 and breast cancer development. The microRNA (miRNA) encoded by mir-155 is known to be oncogenic in multiple tumors. This review summarizes the signaling pathways that are regulated by miR-155 in breast cancer and discusses therapeutic possibilities related to miR-155.
乳腺癌是女性癌症死亡的第二大主要原因。越来越多的证据表明，miR-155 的过度表达与乳腺癌的发生有关。miR-155 编码的 microRNA (miRNA) 已被证实是多种肿瘤的致癌基因。本综述总结了 miR-155 在乳腺癌中调节的信号通路，并讨论了与 miR-155 相关的治疗可能性。
