Department of Dermatology, Research Division of Biology and Pathobiology of the Skin, Medical University of Vienna, Vienna, Austria.
Front Biosci (Landmark Ed). 2012 Jun 1;17(7):2461-75. doi: 10.2741/4065.
Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.
DNA 的降解参与了维持表皮完整性的关键过程，如角质形成细胞的角化、受损细胞的清除以及抵御潜在有害微生物的防御。最近的研究已经描述了表皮中 DNA 降解的一些分子机制和生理功能。脱氧核糖核酸酶 (DNase)1L2 和 TREX2 被鉴定为表皮特异性 DNase，并且 DNase 2 被证明是皮肤表面主要的 DNA 降解酶。在这里，我们回顾了皮肤中 DNA 分解代谢的最新见解，并讨论了与表皮 DNA 断裂的分子生物学相关的未解决问题。
